View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List anti-Ctsk antibody :: Rabbit Cathepsin K Polyclonal Antibody Catalog # MBS840547 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Cathepsin K (Ctsk), Polyclonal Antibody Full Product Name Cathepsin K Antibody Product Synonym Names CTSK; CTS02; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD Product Gene Name anti-Ctsk antibody[Similar Products] Antibody/Peptide Pairs Cathepsin K peptide (MBS843940) is used for blocking the activity of Cathepsin K antibody (MBS840547) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse, Rat Purity/Purification Affinity purified Form/Format 100 ug (0.5 mg/ml) Protein A purified rabbit anti-cathepsin K polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.Appearance: Colorless liquid Concentration 0.5 mg/ml (lot specific) Immunogen Synthetic peptide surrounding amino acid 321 of rat cathepsin K Handling The antibody solution should be gently mixed before use. Preparation and Storage At -20 degree CShelf Life: 12 months Other Notes Small volumes of anti-Ctsk antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-Ctsk antibody Background: Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E. Cathepsin G belongs to the serine protease class. Cathepsins are involved in various cellular events such as peptide biosynthesis, protein degradation, and apoptosis. Cathepsin K expression is highest in bone, cartilage, and skeletal muscle Applications Tested/Suitable for anti-Ctsk antibody Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC) Application Notes for anti-Ctsk antibody Western blotting (0.5-4 ug/ml), immunoprecipitation, and Immunohistochemistry. However, the optimal conditions should be determined individually. Detects 43 kDa cathepsin K of human, mouse, and rat origin. Testing Data of anti-Ctsk antibody TOP NCBI/Uniprot data below describe general gene information for Ctsk. It may not necessarily be applicable to this product. NCBI GI # 13928758 NCBI GeneID 29175 NCBI Accession # NP_113748 [Other Products] NCBI GenBank Nucleotide # NM_031560.2 [Other Products] UniProt Related Accession # O35186[Other Products] Molecular Weight 36,791 Da[Similar Products] TOP NCBI Official Full Name cathepsin K NCBI Official Synonym Full Names cathepsin K NCBI Official Symbol Ctsk [Similar Products] NCBI Protein Information cathepsin K UniProt Protein Name Cathepsin K Protein Family Cathepsin UniProt Gene Name Ctsk [Similar Products] UniProt Entry Name CATK_RAT TOP NCBI Summary for Ctsk putative protease; human homolog displays endoprotease activity and is associated with pycnodysostosis when mutated [RGD, Feb 2006] TOP UniProt Comments for Ctsk CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family.Protein type: EC 3.4.22.38; ProteaseCellular Component: extracellular space; lysosome; cytoplasmMolecular Function: collagen binding; proteoglycan binding; cysteine-type endopeptidase activity; fibronectin binding; cysteine-type peptidase activityBiological Process: collagen catabolic process; intramembranous ossification; proteolysis involved in cellular protein catabolic process; proteolysis; bone resorption Research Articles on Ctsk 1. Comparison of the S2 site between rat and human cathepsin K sequences indicated that two S2 residues at Ser134 and Val160 in rat are varied to Ala and Leu, respectively, in the human enzyme. 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TOP Products associated with anti-Ctsk antibody Reference Product PubMed Publications Tnfsf11 antibody >134 publications with Ctsk and Tnfsf11 Mitf antibody >22 publications with Ctsk and Mitf Mmp13 antibody >9 publications with Ctsk and Mmp13 Bmp2 antibody >6 publications with Ctsk and Bmp2 Mmp7 antibody >4 publications with Ctsk and Mmp7 Tlr9 antibody >3 publications with Ctsk and Tlr9 Col18a1 antibody >1 publications with Ctsk and Col18a1 Tlr7 antibody >1 publications with Ctsk and Tlr7 Pathways associated with anti-Ctsk antibody Products by Pathway Pathway Diagram Activation Of Matrix Metalloproteinases Pathway antibodies Activation Of Matrix Metalloproteinases Pathway Diagram Collagen Degradation Pathway antibodies Collagen Degradation Pathway Diagram Degradation Of The Extracellular Matrix Pathway antibodies Degradation Of The Extracellular Matrix Pathway Diagram Extracellular Matrix Organization Pathway antibodies Extracellular Matrix Organization Pathway Diagram Immune System Pathway antibodies Immune System Pathway Diagram Innate Immune System Pathway antibodies Innate Immune System Pathway Diagram Lysosome Pathway antibodies Lysosome Pathway Diagram Lysosome Pathway antibodies Lysosome Pathway Diagram Osteoclast Pathway antibodies Osteoclast Pathway Diagram Osteoclast Differentiation Pathway antibodies Osteoclast Differentiation Pathway Diagram Diseases associated with anti-Ctsk antibody Disease Name Pubmed Publications Necrosis Antibodies >62 publications with Ctsk and Necrosis Disease Models, Animal Antibodies >58 publications with Ctsk and Disease Models, Animal Pycnodysostosis Antibodies >54 publications with Ctsk and Pycnodysostosis Inflammation Antibodies >49 publications with Ctsk and Inflammation Cardiovascular Diseases Antibodies >32 publications with Ctsk and Cardiovascular Diseases Atherosclerosis Antibodies >22 publications with Ctsk and Atherosclerosis Lung Diseases Antibodies >22 publications with Ctsk and Lung Diseases Nervous System Diseases Antibodies >21 publications with Ctsk and Nervous System Diseases Fibrosis Antibodies >16 publications with Ctsk and Fibrosis Congenital Abnormalities Antibodies >15 publications with Ctsk and Congenital Abnormalities Organs/Tissues associated with anti-Ctsk antibody Organ/Tissue Name Pubmed Publications Connective Tissue Antibodies >112 publications with Ctsk and Connective Tissue Lung Antibodies >41 publications with Ctsk and Lung Artery Antibodies >17 publications with Ctsk and Artery Kidney Antibodies >16 publications with Ctsk and Kidney Heart Antibodies >16 publications with Ctsk and Heart Brain Antibodies >16 publications with Ctsk and Brain Spleen Antibodies >14 publications with Ctsk and Spleen Prostate Antibodies >13 publications with Ctsk and Prostate Embryonic Tissue Antibodies >13 publications with Ctsk and Embryonic Tissue Ovary Antibodies >8 publications with Ctsk and Ovary TOP © 2006-24 MyBioSource.com. 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