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anti-CAV1 antibody :: Rabbit Caveolin-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2537258
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caveolin-1 (CAV1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Caveolin-1 Polyclonal Antibody

 Product Synonym Names    CAV1; CAV; Caveolin-1
 Product Gene Name   

anti-CAV1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601047
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the C-terminal region of human Caveolin-1.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CAV1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CAV1 antibody    Cancer; Epigenetics
 Applications Tested/Suitable for anti-CAV1 antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-CAV1 antibody    WB: 1:500-1:2000, IF: 1:50-1:100, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-CAV1 antibody    Western Blot analysis of various cells using Caveolin-1 Polyclonal Antibody at dilution of 1:1000.
anti-CAV1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CAV1 antibody    Immunohistochemistry of paraffin-embedded Human stomach tissue using Caveolin-1 Polyclonal Antibody at dilution of 1:200.
anti-CAV1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CAV1 antibody    Immunofluorescence analysis of Rat kidney tissue using Caveolin-1 Polyclonal Antibody at dilution of 1:200.
anti-CAV1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CAV1. It may not necessarily be applicable to this product.
 NCBI GI #    290542363
 NCBI GeneID    857
 NCBI Accession #    NP_001166368.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172897.1 [Other Products]
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 UniProt Secondary Accession #    Q9UGP1; Q9UNG1; Q9UQH6 [Other Products]
 UniProt Related Accession #    Q03135 [Other Products]
 Molecular Weight    Calculated MW: 20
Observed MW: 25
[Similar Products]
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 NCBI Official Full Name    caveolin-1 isoform beta
 NCBI Official Synonym Full Names    caveolin 1
 NCBI Official Symbol    CAV1 [Similar Products]
 NCBI Official Synonym Symbols   
CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085
[Similar Products]
 NCBI Protein Information    caveolin-1
 UniProt Protein Name    Caveolin-1
 Protein Family    Caveolin
 UniProt Gene Name    CAV1 [Similar Products]
 UniProt Synonym Gene Names    CAV [Similar Products]
 UniProt Entry Name    CAV1_HUMAN
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 NCBI Summary for CAV1    The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
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 UniProt Comments for CAV1    Caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q31.1

Cellular Component: acrosomal membrane; apical plasma membrane; basal plasma membrane; basolateral plasma membrane; caveola; cell cortex; cell surface; cilium; cytoplasmic vesicle; cytosol; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; focal adhesion; Golgi membrane; integral to plasma membrane; intracellular; lipid particle; lipid raft; membrane; mitochondrion; perinuclear region of cytoplasm; peroxisomal membrane; plasma membrane; protein complex

Molecular Function: ATPase binding; cholesterol binding; enzyme binding; identical protein binding; nitric-oxide synthase binding; patched binding; protease activator activity; protein binding; protein binding, bridging; protein complex scaffold; protein heterodimerization activity; protein kinase binding; Rac GTPase binding; receptor binding; structural molecule activity; syntaxin binding

Biological Process: angiogenesis; blood coagulation; calcium ion homeostasis; calcium ion transport; cellular calcium ion homeostasis; cellular response to starvation; cholesterol efflux; cholesterol homeostasis; cholesterol transport; cytosolic calcium ion homeostasis; inactivation of MAPK activity; lactation; leukocyte migration; maintenance of cellular protein localization; mammary gland development; mammary gland involution; MAPKKK cascade; membrane depolarization; microtubule polymerization; negative regulation of BMP signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of JAK-STAT cascade; negative regulation of MAPKKK cascade; negative regulation of neuron differentiation; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of pinocytosis; negative regulation of protein binding; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat5 protein; nitric oxide homeostasis; nitric oxide metabolic process; organ regeneration; positive regulation of endocytosis; positive regulation of endothelial cell proliferation; positive regulation of metalloenzyme activity; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of vasoconstriction; protein homooligomerization; protein localization; receptor internalization; receptor mediated endocytosis of virus by host; regulation of blood coagulation; regulation of fatty acid metabolic process; regulation of nitric-oxide synthase activity; regulation of peptidase activity; regulation of smooth muscle contraction; regulation of the force of heart contraction by chemical signal; response to bacterium; response to calcium ion; response to drug; response to estrogen stimulus; response to gamma radiation; response to glucocorticoid stimulus; response to hypoxia; response to nutrient; response to progesterone stimulus; sequestering of lipid; skeletal muscle development; T cell costimulation; triacylglycerol metabolic process; vascular endothelial growth factor receptor signaling pathway; vasculogenesis; vasoconstriction; vesicle organization and biogenesis

Disease: Lipodystrophy, Congenital Generalized, Type 3; Partial Lipodystrophy, Congenital Cataracts, And Neurodegeneration Syndrome; Pulmonary Hypertension, Primary, 3
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 Research Articles on CAV1    1. Under the regulation of Rab5, the fused vesicles are targeted to early endosomes and thus deliver the internalized TbetaRI to the caveolin-1 and EEA1 double-positive early endosomes (caveolin-1-positive early endosomes).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CAV1 antibodyPathways associated with anti-CAV1 antibody
 Reference Product  PubMed Publications
 CAV2 antibody  >183 publications with CAV1 and CAV2
 SRC antibody  >145 publications with CAV1 and SRC
 NOS3 antibody  >105 publications with CAV1 and NOS3
 EGFR antibody  >47 publications with CAV1 and EGFR
 FYN antibody  >25 publications with CAV1 and FYN
 TRPC1 antibody  >15 publications with CAV1 and TRPC1
 TP53 antibody  >7 publications with CAV1 and TP53
 TGFBR1 antibody  >1 publications with CAV1 and TGFBR1
 PTPN1 antibody  >1 publications with CAV1 and PTPN1
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway antibodies  Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
Diseases associated with anti-CAV1 antibodyOrgans/Tissues associated with anti-CAV1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >213 publications with CAV1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >129 publications with CAV1 and Heart Diseases
 Lung Diseases Antibodies  >108 publications with CAV1 and Lung Diseases
 Hypertension Antibodies  >100 publications with CAV1 and Hypertension
 Breast Neoplasms Antibodies  >99 publications with CAV1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >82 publications with CAV1 and Adenocarcinoma
 Inflammation Antibodies  >82 publications with CAV1 and Inflammation
 Neoplasm Metastasis Antibodies  >75 publications with CAV1 and Neoplasm Metastasis
 Fibrosis Antibodies  >64 publications with CAV1 and Fibrosis
 Prostatic Neoplasms Antibodies  >60 publications with CAV1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >578 publications with CAV1 and Muscle
 Vascular Antibodies  >435 publications with CAV1 and Vascular
 Heart Antibodies  >338 publications with CAV1 and Heart
 Brain Antibodies  >312 publications with CAV1 and Brain
 Blood Antibodies  >299 publications with CAV1 and Blood
 Lung Antibodies  >206 publications with CAV1 and Lung
 Kidney Antibodies  >154 publications with CAV1 and Kidney
 Nerve Antibodies  >123 publications with CAV1 and Nerve
 Liver Antibodies  >107 publications with CAV1 and Liver
 Prostate Antibodies  >85 publications with CAV1 and Prostate
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