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anti-CAV1 antibody :: Rabbit anti-Human Caveolin 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS630202 anti-CAV1 antibody
Unit / Price
0.1 mL  /  $525 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caveolin 1 (CAV1), Polyclonal Antibody

 Also Known As   

Caveolin 1, phosphorylated (Tyr14) (CAV1, caveolae protein, 22kD, HGNC:1527, CAV, MSTP085, VIP21, caveolin 1, alpha isoform, caveolin 1, beta isoform, cell growth-inhibiting protein 32)

 Product Synonym Names    Anti -Caveolin 1, phosphorylated (Tyr14) (CAV1, caveolae protein, 22kD, HGNC:1527, CAV, MSTP085, VIP21, caveolin 1, alpha isoform, caveolin 1, beta isoform, cell growth-inhibiting protein 32)
 Product Gene Name   

anti-CAV1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (116164839..116201239). Location: 7q31.1
 OMIM    601047
 3D Structure    ModBase 3D Structure for Q03135
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Detects endogenous levels of caveolin-1 phosphorylated at tyrosine 14. Does not crossreact with caveolin-2, -3 or caveolin-1beta, the short isoform of caveolin-1.
 Purity/Purification    Affinity Purified
Purified by protein A and peptide affinity chromatography.
 Form/Format    Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100 ug/ml BSA, 50% glycerol.
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 Immunogen    Synthetic phosphopeptide (KLH coupled) corresponding to residues surrounding Tyr14 of human caveolin-1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CAV1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CAV1 antibody

   The 21-24kD integral proteins, caveolins, are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of caveolins (caveolin-1, -2 and -3) have been identified with different tissue distributions. Caveolins form hetero-and homooligomers, which interact with cholesterol and other lipids (1). Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion and apoptosis. It is also implicated in neurodegenerative disease (2). Caveolins also interact with multiple signaling molecules, such as G-alpha subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS (1,2). It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Tyrosine 14 has been identified as one of the tyrosine phosphorylation sites on caveolin-1 (3,4). Phosphorylation at Tyr14 is essential for its association with SH2 or PTB domaincontaining adaptor proteins, such as GRB7 (5). Phosphorylation at serine 80 is a key regulatory event for its binding to the ER membrane and entry into the secretory pathway (6).
 Product Categories/Family for anti-CAV1 antibody    Antibodies; Abs to Membrane Proteins
 Applications Tested/Suitable for anti-CAV1 antibody   

Western Blot (WB)

 Application Notes for anti-CAV1 antibody    Suitable for use in Western Blot
Dilution: Western Blot: 1:1000
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NCBI/Uniprot data below describe general gene information for CAV1. It may not necessarily be applicable to this product.
 NCBI GI #    4972627
 NCBI GeneID    857
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 UniProt Primary Accession #    Q03135 [Other Products]
 UniProt Secondary Accession #    Q9UGP1; Q9UNG1; Q9UQH6 [Other Products]
 UniProt Related Accession #    Q03135; Q2TNI1; Q59E85; Q71VB8; Q7Z4F3 [Other Products]
 Molecular Weight    20,472 Da [Similar Products]
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 NCBI Official Full Name    caveolin 1
 NCBI Official Synonym Full Names    caveolin 1, caveolae protein, 22kDa
 NCBI Official Symbol    CAV1 [Similar Products]
 NCBI Official Synonym Symbols   
CGL3; BSCL3; VIP21; MSTP085
[Similar Products]
 NCBI Protein Information    caveolin-1; OTTHUMP00000025031; OTTHUMP00000195988; OTTHUMP00000195989; OTTHUMP00000196475; OTTHUMP00000198308; cell growth-inhibiting protein 32
 UniProt Protein Name    Caveolin-1
 Protein Family    Caveolin
 UniProt Gene Name    CAV1 [Similar Products]
 UniProt Synonym Gene Names    CAV [Similar Products]
 UniProt Entry Name    CAV1_HUMAN
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 NCBI Summary for CAV1    The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
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 UniProt Comments for CAV1    Caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q31.1

Cellular Component: protein complex; focal adhesion; basolateral plasma membrane; integral to plasma membrane; endoplasmic reticulum; lipid particle; cell cortex; caveola; acrosomal membrane; lipid raft; cilium; Golgi membrane; early endosome membrane; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; intracellular; cytoplasmic vesicle; endosome

Molecular Function: identical protein binding; protein binding; protease activator activity; enzyme binding; cholesterol binding; patched binding; protein complex scaffold; nitric-oxide synthase binding; structural molecule activity; protein kinase binding; receptor binding

Biological Process: mammary gland involution; viral reproduction; negative regulation of epithelial cell differentiation; negative regulation of tyrosine phosphorylation of Stat5 protein; nitric oxide homeostasis; negative regulation of BMP signaling pathway; calcium ion homeostasis; protein localization; sequestering of lipid; regulation of the force of heart contraction by chemical signal; regulation of fatty acid metabolic process; negative regulation of protein binding; inactivation of MAPK activity; regulation of smooth muscle contraction; maintenance of cellular protein localization; skeletal muscle development; cytosolic calcium ion homeostasis; negative regulation of nitric-oxide synthase activity; cellular response to starvation; membrane depolarization; cholesterol homeostasis; response to estrogen stimulus; T cell costimulation; negative regulation of endothelial cell proliferation; negative regulation of protein ubiquitination; regulation of nitric-oxide synthase activity; response to calcium ion; response to progesterone stimulus; leukocyte migration; negative regulation of JAK-STAT cascade; lactation; vesicle organization and biogenesis; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of pinocytosis; nitric oxide metabolic process; mammary gland development; calcium ion transport; negative regulation of cytokine and chemokine mediated signaling pathway; angiogenesis; vasculogenesis; protein homooligomerization; vasoconstriction; cholesterol transport; negative regulation of MAPKKK cascade; negative regulation of nitric oxide biosynthetic process; MAPKKK cascade; positive regulation of metalloenzyme activity; positive regulation of peptidyl-serine phosphorylation; regulation of peptidase activity; cellular calcium ion homeostasis; triacylglycerol metabolic process; regulation of blood coagulation; response to hypoxia; positive regulation of vasoconstriction; blood coagulation; vascular endothelial growth factor receptor signaling pathway

Disease: Lipodystrophy, Congenital Generalized, Type 3; Partial Lipodystrophy, Congenital Cataracts, And Neurodegeneration Syndrome; Pulmonary Hypertension, Primary, 3
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 Research Articles on CAV1    1. In the presence of Cav-1, phosphorylation of IKKbeta, IKKalpha, IkappaBalpha, and NF-kappaB p65 is dramatically reduced, while HIV-1 viral gene expression is suppressed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CAV1 antibodyPathways associated with anti-CAV1 antibody
 Reference Product  PubMed Publications
 SRC antibody  >109 publications with CAV1 and SRC
 CAV2 antibody  >95 publications with CAV1 and CAV2
 NOS3 antibody  >56 publications with CAV1 and NOS3
 MAPK3 antibody  >27 publications with CAV1 and MAPK3
 EGFR antibody  >27 publications with CAV1 and EGFR
 MAPK1 antibody  >26 publications with CAV1 and MAPK1
 ABCB1 antibody  >23 publications with CAV1 and ABCB1
 RHOA antibody  >22 publications with CAV1 and RHOA
 FYN antibody  >21 publications with CAV1 and FYN
 CSK antibody  >13 publications with CAV1 and CSK
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with anti-CAV1 antibodyOrgans/Tissues associated with anti-CAV1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >277 publications with CAV1 and Neoplasms
 Carcinoma Antibodies  >118 publications with CAV1 and Carcinoma
 Cardiovascular Diseases Antibodies  >77 publications with CAV1 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >58 publications with CAV1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >51 publications with CAV1 and Adenocarcinoma
 Lung Diseases Antibodies  >49 publications with CAV1 and Lung Diseases
 Prostatic Neoplasms Antibodies  >41 publications with CAV1 and Prostatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >40 publications with CAV1 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >39 publications with CAV1 and Neoplasm Metastasis
 Heart Diseases Antibodies  >39 publications with CAV1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >295 publications with CAV1 and Muscle
 Vascular Antibodies  >240 publications with CAV1 and Vascular
 Brain Antibodies  >159 publications with CAV1 and Brain
 Heart Antibodies  >155 publications with CAV1 and Heart
 Blood Antibodies  >155 publications with CAV1 and Blood
 Lung Antibodies  >100 publications with CAV1 and Lung
 Kidney Antibodies  >92 publications with CAV1 and Kidney
 Nerve Antibodies  >61 publications with CAV1 and Nerve
 Prostate Antibodies  >57 publications with CAV1 and Prostate
 Embryonic Tissue Antibodies  >54 publications with CAV1 and Embryonic Tissue
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