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anti-Cbs antibody :: Rabbit anti-Mouse Cbs Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7005693
Immunofluorescence (IF)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cbs, Polyclonal Antibody

★Popular Item★
 Also Known As   

Cbs Antibody

 Product Synonym Names    Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; Cbs
 Product Gene Name   

anti-Cbs antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q91WT9
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant mouse Cystathionine beta-synthase protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-Cbs antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Cbs antibody

   Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
 Applications Tested/Suitable for anti-Cbs antibody   

ELISA (EIA), Immunofluorescence (IF)

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 Immunofluorescence (IF) of anti-Cbs antibody    Immunofluorescent analysis of Hela cells using MBS7005693 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-Cbs antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for Cbs. It may not necessarily be applicable to this product.
 NCBI GI #    405778333
 NCBI GeneID    12411
 NCBI Accession #    NP_001258282.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001271353.1 [Other Products]
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 UniProt Primary Accession #    Q91WT9 [Other Products]
 UniProt Secondary Accession #    Q91WU3 [Other Products]
 UniProt Related Accession #    Q91WT9 [Other Products]
 Molecular Weight    60,193 Da
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 NCBI Official Full Name    cystathionine beta-synthase isoform 2
 NCBI Official Synonym Full Names    cystathionine beta-synthase
 NCBI Official Symbol    Cbs [Similar Products]
 NCBI Official Synonym Symbols   
HIP4; AI047524; AI303044
[Similar Products]
 NCBI Protein Information    cystathionine beta-synthase
 UniProt Protein Name    Cystathionine beta-synthase
 UniProt Synonym Protein Names   
Beta-thionase; Serine sulfhydrase
 Protein Family    Cystathionine beta-synthase
 UniProt Gene Name    Cbs [Similar Products]
 UniProt Entry Name    CBS_MOUSE
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 UniProt Comments for Cbs    CBS: Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury. Defects in CBS are the cause of cystathionine beta- synthase deficiency (CBSD). CBSD is an enzymatic deficiency resulting in altered sulfur metabolism and homocystinuria. The clinical features of untreated homocystinuria due to CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events. Light skin and hair can also be present. Biochemical features include increased urinary homocystine and methionine. Belongs to the cysteine synthase/cystathionine beta- synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Other Amino Acids Metabolism - selenoamino acid; Lyase; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; EC 4.2.1.22

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: cystathionine beta-synthase activity; cysteine synthase activity; enzyme binding; heme binding; identical protein binding; lyase activity; metal ion binding; nitrite reductase (NO-forming) activity; oxygen binding; protein homodimerization activity; pyridoxal phosphate binding; ubiquitin protein ligase binding

Biological Process: amino acid biosynthetic process; blood vessel remodeling; cerebellum morphogenesis; cysteine biosynthetic process; cysteine biosynthetic process from serine; cysteine biosynthetic process via cystathionine; endochondral ossification; homocysteine metabolic process; maternal process involved in pregnancy; negative regulation of apoptosis; regulation of blood vessel size; regulation of cGMP metabolic process; regulation of JNK activity; response to folic acid; superoxide metabolic process; transsulfuration
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 Research Articles on Cbs    1. These data confirm a key role for the H2S-generating enzymes Cbs and Cth in pulmonary vascular development and homeostasis and in lung alveolarization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Cbs antibodyPathways associated with anti-Cbs antibody
 Reference Product  PubMed Publications
 Mtr antibody  >84 publications with Cbs and Mtr
 Sds antibody  >38 publications with Cbs and Sds
 Cth antibody  >25 publications with Cbs and Cth
 Shmt1 antibody  >22 publications with Cbs and Shmt1
 Shmt2 antibody  >1 publications with Cbs and Shmt2
 Products by Pathway  Pathway Diagram
 Amino Acid Metabolism Pathway antibodies  Amino Acid Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Formation From Homocysteine Pathway antibodies  Cysteine Formation From Homocysteine Pathway Diagram
 Folic Acid Network Pathway antibodies  Folic Acid Network Pathway Diagram
 Glutathione And One Carbon Metabolism Pathway antibodies  Glutathione And One Carbon Metabolism Pathway Diagram
Diseases associated with anti-Cbs antibodyOrgans/Tissues associated with anti-Cbs antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >549 publications with Cbs and Brain Diseases
 Cardiovascular Diseases Antibodies  >377 publications with Cbs and Cardiovascular Diseases
 Hyperhomocysteinemia Antibodies  >372 publications with Cbs and Hyperhomocysteinemia
 Homocystinuria Antibodies  >199 publications with Cbs and Homocystinuria
 Neurobehavioral Manifestations Antibodies  >195 publications with Cbs and Neurobehavioral Manifestations
 Malnutrition Antibodies  >182 publications with Cbs and Malnutrition
 Inflammation Antibodies  >142 publications with Cbs and Inflammation
 Heart Diseases Antibodies  >137 publications with Cbs and Heart Diseases
 Congenital Abnormalities Antibodies  >99 publications with Cbs and Congenital Abnormalities
 Liver Diseases Antibodies  >78 publications with Cbs and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1089 publications with Cbs and Brain
 Liver Antibodies  >257 publications with Cbs and Liver
 Eye Antibodies  >134 publications with Cbs and Eye
 Kidney Antibodies  >126 publications with Cbs and Kidney
 Lung Antibodies  >104 publications with Cbs and Lung
 Skin Antibodies  >96 publications with Cbs and Skin
 Bone Antibodies  >71 publications with Cbs and Bone
 Intestine Antibodies  >62 publications with Cbs and Intestine
 Spinal Cord Antibodies  >51 publications with Cbs and Spinal Cord
 Embryonic Tissue Antibodies  >36 publications with Cbs and Embryonic Tissue
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