NP_001780.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,551 Da
NCBI Official Full Name
M-phase inducer phosphatase 1 isoform a
NCBI Official Synonym Full Names
cell division cycle 25A
NCBI Official Synonym Symbols
NCBI Protein Information
M-phase inducer phosphatase 1
UniProt Protein Name
M-phase inducer phosphatase 1
UniProt Synonym Protein Names
Dual specificity phosphatase Cdc25A
NCBI Summary for Cdc25A
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for Cdc25A
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Research Articles on Cdc25A
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Products associated with anti-Cdc25A antibody
Pathways associated with anti-Cdc25A antibody
Diseases associated with anti-Cdc25A antibody
Organs/Tissues associated with anti-Cdc25A antibody
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