NP_008996.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
hsp90 co-chaperone Cdc37
NCBI Official Synonym Full Names
cell division cycle 37
NCBI Official Synonym Symbols
NCBI Protein Information
hsp90 co-chaperone Cdc37; cell division cycle 37 homolog; CDC37 cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; CDC37 (cell division cycle 37, S. cerevisiae, homolog)
UniProt Protein Name
Hsp90 co-chaperone Cdc37
UniProt Synonym Protein Names
Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37Cleaved into the following chain:Hsp90 co-chaperone Cdc37, N-terminally processed
UniProt Synonym Gene Names
UniProt Entry Name
CDC37_HUMAN
NCBI Summary for CDC37
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
UniProt Comments for CDC37
CDC37: a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: protein complex; cytoplasm; cytosol
Molecular Function: protein kinase B binding; protein binding; chaperone binding; heat shock protein binding; unfolded protein binding; mitogen-activated protein kinase kinase kinase binding; Hsp90 protein binding; kinase binding
Biological Process: protein stabilization; protein folding; regulation of cyclin-dependent protein kinase activity; protein targeting
Product References and Citations for anti-CDC37 antibody
1. Dai K, Kobayashi R., Beach D. (1996) J Biol Chem. 271(36): 22030-22034. 2. Stepanova L, Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10(12): 1491-1502. 3. Kimura Y., et al. (1997) Genes Dev. 11(14): 1775- 1185. 4. Gray P.J., et al. (2008) Nat Rev Cancer. 8(7): 491- 495.
Research Articles on CDC37
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Products associated with anti-CDC37 antibody
Pathways associated with anti-CDC37 antibody
Diseases associated with anti-CDC37 antibody
Organs/Tissues associated with anti-CDC37 antibody
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