NP_006491.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,605 Da
NCBI Official Full Name
cell surface glycoprotein MUC18
NCBI Official Synonym Full Names
melanoma cell adhesion molecule
NCBI Official Synonym Symbols
NCBI Protein Information
cell surface glycoprotein MUC18
UniProt Protein Name
Cell surface glycoprotein MUC18
UniProt Synonym Protein Names
Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen: CD146
UniProt Synonym Gene Names
UniProt Entry Name
MUC18_HUMAN
UniProt Comments for MUC18
MCAM: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: external side of plasma membrane; extracellular space; focal adhesion; integral to membrane; nucleus; plasma membrane
Biological Process: anatomical structure morphogenesis; angiogenesis; cell adhesion; glomerular filtration; positive regulation of cell migration
Research Articles on MUC18
Precautions
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Products associated with anti-MUC18 antibody
Diseases associated with anti-MUC18 antibody
Organs/Tissues associated with anti-MUC18 antibody
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