NP_004581.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,600 Da
NCBI Official Full Name
C-C motif chemokine 16
NCBI Official Synonym Full Names
C-C motif chemokine ligand 16
NCBI Official Synonym Symbols
LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16 [Similar Products]
NCBI Protein Information
C-C motif chemokine 16
UniProt Protein Name
C-C motif chemokine 16
UniProt Synonym Protein Names
Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16
UniProt Synonym Gene Names
NCBI Summary for CCL16
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]
UniProt Comments for CCL16
CCL16: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: extracellular region; extracellular space
Molecular Function: CCR chemokine receptor binding; chemoattractant activity; chemokine activity
Biological Process: cell communication; cell-cell signaling; chemotaxis; G-protein coupled receptor signaling pathway; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive chemotaxis; positive regulation of GTPase activity
Research Articles on CCL16
Precautions
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Disclaimer
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Products associated with anti-CCL16 antibody
Pathways associated with anti-CCL16 antibody
Diseases associated with anti-CCL16 antibody
Disease Name |
Pubmed Publications |
Neoplasms, Experimental Antibodies |
>9 publications with CCL16 and Neoplasms, Experimental |
Inflammation Antibodies |
>9 publications with CCL16 and Inflammation |
Necrosis Antibodies |
>7 publications with CCL16 and Necrosis |
Disease Models, Animal Antibodies |
>6 publications with CCL16 and Disease Models, Animal |
Adenocarcinoma Antibodies |
>4 publications with CCL16 and Adenocarcinoma |
Liver Diseases Antibodies |
>3 publications with CCL16 and Liver Diseases |
Mammary Neoplasms, Animal Antibodies |
>3 publications with CCL16 and Mammary Neoplasms, Animal |
Lung Neoplasms Antibodies |
>2 publications with CCL16 and Lung Neoplasms |
Carcinoma, Hepatocellular Antibodies |
>1 publications with CCL16 and Carcinoma, Hepatocellular |
Liver Neoplasms, Experimental Antibodies |
>1 publications with CCL16 and Liver Neoplasms, Experimental |
Organs/Tissues associated with anti-CCL16 antibody
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