EAW63552.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,140 Da
NCBI Official Full Name
cholinergic receptor, nicotinic, alpha 2 (neuronal)
NCBI Official Synonym Full Names
cholinergic receptor nicotinic alpha 2 subunit
NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-2
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-2
NCBI Summary for CHRNa2
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]
UniProt Comments for CHRNa2
nAChRA2: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNA2 are the cause of nocturnal frontal lobe epilepsy type 4 (ENFL4). ENFL4 is an autosomal dominant epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 2/CHRNA2 sub-subfamily.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; plasma membrane
Molecular Function: acetylcholine binding; acetylcholine receptor activity; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity
Biological Process: neuromuscular synaptic transmission; response to nicotine; signal transduction; synaptic transmission, cholinergic
Disease: Epilepsy, Nocturnal Frontal Lobe, 4
Research Articles on CHRNa2
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Products associated with anti-CHRNa2 antibody
Pathways associated with anti-CHRNa2 antibody
Diseases associated with anti-CHRNa2 antibody
Organs/Tissues associated with anti-CHRNa2 antibody
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