NP_000735.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,994 Da
NCBI Official Full Name
neuronal acetylcholine receptor subunit alpha-4 isoform 1
NCBI Official Synonym Full Names
cholinergic receptor nicotinic alpha 4 subunit
NCBI Official Synonym Symbols
EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4 [Similar Products]
NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-4
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-4
UniProt Synonym Gene Names
NCBI Summary for CHRNa4
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
UniProt Comments for CHRNa4
nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: acetylcholine-gated channel complex; cell junction; cell soma; dendrite; external side of plasma membrane; integral component of membrane; membrane; plasma membrane; postsynaptic membrane
Molecular Function: acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation channel activity; ligand-gated ion channel activity; protein binding
Biological Process: B cell activation; behavioral response to nicotine; calcium ion transport; cognition; DNA repair; excitatory postsynaptic potential; inhibitory postsynaptic potential; ion transport; locomotory behavior; membrane depolarization; neurological system process; neuromuscular synaptic transmission; regulation of action potential; regulation of dopamine secretion; regulation of membrane potential; respiratory gaseous exchange; response to hypoxia; response to nicotine; response to oxidative stress; sensory perception of pain; signal transduction; synaptic transmission; synaptic transmission, cholinergic
Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To
Research Articles on CHRNa4
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Products associated with anti-CHRNa4 antibody
Pathways associated with anti-CHRNa4 antibody
Diseases associated with anti-CHRNa4 antibody
Organs/Tissues associated with anti-CHRNa4 antibody
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