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anti-CHRDL1 antibody :: Rabbit anti-Mouse Chordin Like Protein 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2028812 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $185 +1 FREE 8GB USB
0.1 mg  /  $230 +1 FREE 8GB USB
0.2 mg  /  $345 +1 FREE 8GB USB
1 mg  /  $825 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Chordin Like Protein 1 (CHRDL1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Chordin Like Protein 1 (CHRDL1)

 Product Gene Name   

anti-CHRDL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q920C1
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    The antibody is a rabbit polyclonal antibody raised against CHRDL1. It has beenselected for its ability to recognize CHRDL1 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    CHRDL1 (Leu272~Cys447)
 Organism Species    Mus musculus (Mouse)
 Conjugate    No Conjugate
 Immunogen    Recombinant CHRDL1 (Leu272~Cys447) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2076961
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-CHRDL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CHRDL1 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-CHRDL1 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-CHRDL1 antibody    Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) Knockout Verification of anti-CHRDL1 antibody    Knockout Verification: Lane 1: Wild-type 293T cell lysate; Lane 2: CHRDL1 knockout 293T cell lysate; Predicted MW: 51,37kd Observed MW: 40kd Primary Ab: 2ug/ml Rabbit Anti-Mouse CHRDL1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-CHRDL1 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-CHRDL1 antibody    Western Blot; Sample: Human 293T cell lysate; Primary Ab: 2ug/ml Rabbit Anti-Mouse CHRDL1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-CHRDL1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-CHRDL1 antibody    Western Blot; Sample: Recombinant protein.
anti-CHRDL1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CHRDL1 antibody    DAB staining on fromalin fixed paraffin- embedded brain tissue)
anti-CHRDL1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CHRDL1. It may not necessarily be applicable to this product.
 NCBI GI #    167466239
 NCBI GeneID    83453
 NCBI Accession #    NP_001107857.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114385.1 [Other Products]
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 UniProt Primary Accession #    Q920C1 [Other Products]
 UniProt Secondary Accession #    Q924K0; Q9EPZ9 [Other Products]
 UniProt Related Accession #    Q920C1 [Other Products]
 Molecular Weight    37,034 Da
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 NCBI Official Full Name    chordin-like protein 1 isoform 1
 NCBI Official Synonym Full Names    chordin-like 1
 NCBI Official Symbol    Chrdl1 [Similar Products]
 NCBI Official Synonym Symbols   
CHL; CHL1; VOPT; Nrln1
[Similar Products]
 NCBI Protein Information    chordin-like protein 1
 UniProt Protein Name    Chordin-like protein 1
 UniProt Synonym Protein Names   
Neuralin-1; Neurogenesin-1; Ventroptin
 Protein Family    Chordin-like protein
 UniProt Gene Name    Chrdl1 [Similar Products]
 UniProt Synonym Gene Names    Ng1; Nrln1 [Similar Products]
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 UniProt Comments for CHRDL1    CHRDL1: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. Defects in CHRDL1 are the cause of megalocornea type 1, X-linked (MGC1). MGC1 is an eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: X|X F2

Cellular Component: extracellular region

Biological Process: cell differentiation; cell fate determination; compound eye development; eye development; multicellular organism development; negative regulation of BMP signaling pathway; nervous system development; neuron differentiation; ossification
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 Research Articles on CHRDL1    1. CHRDL-1 is a new regulatory target of miR-134 during cortical neuronal differentiation; this is a novel role for miR-134 in the modulation of cortical development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CHRDL1 antibodyDiseases associated with anti-CHRDL1 antibody
 Products by Pathway  Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with CHRDL1 and Neoplasms
 Carcinoma Antibodies  >2 publications with CHRDL1 and Carcinoma
 Acute Kidney Injury Antibodies  >2 publications with CHRDL1 and Acute Kidney Injury
 Nervous System Malformations Antibodies  >1 publications with CHRDL1 and Nervous System Malformations
 Renal Insufficiency Antibodies  >1 publications with CHRDL1 and Renal Insufficiency
 Craniofacial Abnormalities Antibodies  >1 publications with CHRDL1 and Craniofacial Abnormalities
 Neoplasms, Experimental Antibodies  >1 publications with CHRDL1 and Neoplasms, Experimental
 Fibrosis Antibodies  >1 publications with CHRDL1 and Fibrosis
 Skin Diseases Antibodies  >1 publications with CHRDL1 and Skin Diseases
 Carcinoma, Squamous Cell Antibodies  >1 publications with CHRDL1 and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-CHRDL1 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >15 publications with CHRDL1 and Eye
 Bone Antibodies  >13 publications with CHRDL1 and Bone
 Embryonic Tissue Antibodies  >6 publications with CHRDL1 and Embryonic Tissue
 Brain Antibodies  >2 publications with CHRDL1 and Brain
 Intestine Antibodies  >1 publications with CHRDL1 and Intestine
 Skin Antibodies  >1 publications with CHRDL1 and Skin
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