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anti-CLTC antibody :: Rabbit Clathrin, Heavy Chain Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS610138
Unit / Price
0.1 mL  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Clathrin, Heavy Chain (CLTC), Polyclonal Antibody

★Popular Item★
 Also Known As   

Clathrin, Heavy Chain

 Product Synonym Names    Anti -Clathrin, Heavy Chain
 Product Gene Name   

anti-CLTC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (57697050..57774317). Location: 17q11-qter
 OMIM    118955
 3D Structure    ModBase 3D Structure for Q00610
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Bovine, Human, Monkey, Mouse, Rat
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 Specificity    Recognizes endogenous levels of total human Clathrin protein at 190 kD.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA and 50% glycerol.
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 Immunogen    Synthetic peptide corresponding to residues surrounding Pro1663 of human Clathrin (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CLTC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CLTC antibody

   Clathrin-coated pits, intracellular transport vesicles involved in endocytosis and other membrane trafficking processes, are multi-component units. (1,2). Clathrin, the most abundant protein in these vesicles, is formed of a basic assembly unit called a triskelion composed of three clathrin heavy chains and three clathrin light chains. Together with other coat components such as AP2, epsin and EPS15, triskelia are targeted to appropriate membrane fusion sites, where subsequent invagination, cargo protein uptake and vesicle internalization occurs (3,4).
 Product Categories/Family for anti-CLTC antibody    Antibodies; Abs to Clathrin
 Applications Tested/Suitable for anti-CLTC antibody   

ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-CLTC antibody    Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunocytochemistry.
Dilution: Western Blot: 1:1000
Immunofluorescence (IF-IC): 1:400
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 Western Blot of anti-CLTC antibody    Western Blot of extrats from SHSYSY, Neuro2A, PC12 aNone DetectedCOS cells
anti-CLTC antibody Western Blot (WB) image
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 Immunofluorescent of anti-CLTC antibody    Confocal immunofluorescent analysis of HeLa cells labeled with MBS610138 (green). Blue pseudocolor = DRAQSTM (fluorescent DNA dye).
anti-CLTC antibody Immunofluorescent image
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NCBI/Uniprot data below describe general gene information for CLTC. It may not necessarily be applicable to this product.
 NCBI GI #    4758012
 NCBI GeneID    1213
 NCBI Accession #    NP_004850.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004859.3 [Other Products]
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 UniProt Primary Accession #    Q00610 [Other Products]
 UniProt Secondary Accession #    Q6N0A0; Q86TF2; D3DU00 [Other Products]
 UniProt Related Accession #    Q00610; Q49AL0 [Other Products]
 Molecular Weight    191,615 Da [Similar Products]
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 NCBI Official Full Name    clathrin heavy chain 1
 NCBI Official Synonym Full Names    clathrin, heavy chain (Hc)
 NCBI Official Symbol    CLTC [Similar Products]
 NCBI Official Synonym Symbols   
Hc; CHC; CHC17; CLH-17; CLTCL2; KIAA0034
[Similar Products]
 NCBI Protein Information    clathrin heavy chain 1; OTTHUMP00000165784; OTTHUMP00000165785; clathrin, heavy polypeptide (Hc); clathrin, heavy polypeptide-like 2; clathrin heavy chain on chromosome 17
 UniProt Protein Name    Clathrin heavy chain 1
 UniProt Synonym Protein Names   
Clathrin heavy chain on chromosome 17
 Protein Family    Clathrin
 UniProt Gene Name    CLTC [Similar Products]
 UniProt Synonym Gene Names    CLH17; CLTCL2; KIAA0034 [Similar Products]
 UniProt Entry Name    CLH1_HUMAN
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 NCBI Summary for CLTC    Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq]
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 UniProt Comments for CLTC    CLTC: a major protein component of the cytoplasmic face of coated vesicles and coated pits. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.

Protein type: Vesicle; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: clathrin coat of trans-Golgi network vesicle; clathrin coat; focal adhesion; protein complex; clathrin-coated vesicle; intracellular membrane-bound organelle; cytosol; clathrin coat of coated pit; membrane; cytoplasm; melanosome; plasma membrane; trans-Golgi network membrane; spindle; vesicle

Molecular Function: protein binding; double-stranded RNA binding; structural molecule activity; protein kinase binding; clathrin light chain binding

Biological Process: osteoblast differentiation; mitosis; receptor-mediated endocytosis; intracellular protein transport; receptor internalization; transferrin transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; post-Golgi vesicle-mediated transport
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 Research Articles on CLTC    1. The authors now report that the integrase domain of Gag-Pol is required for the incorporation of clathrin into HIV-1 virions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLTC antibodyPathways associated with anti-CLTC antibody
 Reference Product  PubMed Publications
 CLTA antibody  >3 publications with CLTC and CLTA
 CLTB antibody  >2 publications with CLTC and CLTB
 ARRB1 antibody  >1 publications with CLTC and ARRB1
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 EGFR Downregulation Pathway antibodies  EGFR Downregulation Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with anti-CLTC antibodyOrgans/Tissues associated with anti-CLTC antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >26 publications with CLTC and Neoplasms
 Lymphoma Antibodies  >24 publications with CLTC and Lymphoma
 Carcinoma Antibodies  >7 publications with CLTC and Carcinoma
 Adenocarcinoma Antibodies  >5 publications with CLTC and Adenocarcinoma
 Kidney Diseases Antibodies  >4 publications with CLTC and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with CLTC and Cell Transformation, Neoplastic
 Carcinoma, Renal Cell Antibodies  >4 publications with CLTC and Carcinoma, Renal Cell
 Female Urogenital Diseases Antibodies  >4 publications with CLTC and Female Urogenital Diseases
 Carcinoma, Small Cell Antibodies  >3 publications with CLTC and Carcinoma, Small Cell
 Urologic Neoplasms Antibodies  >3 publications with CLTC and Urologic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >7 publications with CLTC and Muscle
 Lymph Node Antibodies  >4 publications with CLTC and Lymph Node
 Kidney Antibodies  >4 publications with CLTC and Kidney
 Lymph Antibodies  >4 publications with CLTC and Lymph
 Bone Marrow Antibodies  >3 publications with CLTC and Bone Marrow
 Blood Antibodies  >3 publications with CLTC and Blood
 Bone Antibodies  >3 publications with CLTC and Bone
 Lung Antibodies  >2 publications with CLTC and Lung
 Stomach Antibodies  >2 publications with CLTC and Stomach
 Spleen Antibodies  >1 publications with CLTC and Spleen
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