P56747.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,292 Da
NCBI Official Full Name
Claudin-6
NCBI Official Synonym Full Names
claudin 6
NCBI Protein Information
claudin-6; skullin
UniProt Protein Name
Claudin-6
UniProt Synonym Protein Names
Skullin
UniProt Entry Name
CLD6_HUMAN
NCBI Summary for CLDN6
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
UniProt Comments for CLDN6
Claudin-6: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: tight junction; integral to membrane; plasma membrane
Molecular Function: identical protein binding; structural molecule activity
Biological Process: intercellular junction assembly and maintenance; viral reproduction; calcium-independent cell-cell adhesion
Research Articles on CLDN6
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Products associated with anti-CLDN6 antibody
Pathways associated with anti-CLDN6 antibody
Diseases associated with anti-CLDN6 antibody
Organs/Tissues associated with anti-CLDN6 antibody
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