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anti-NOTCH2 antibody :: Rabbit Cleaved-Notch 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9410510
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cleaved-Notch 2 (NOTCH2), Polyclonal Antibody

 Also Known As   

Cleaved-Notch 2 (D1733) Polyclonal Antibody

 Product Synonym Names    NOTCH2; Neurogenic locus notch homolog protein 2; Notch 2; hN2
 Product Gene Name   

anti-NOTCH2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102500
 3D Structure    ModBase 3D Structure for Q04721
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Cleaved-Notch 2 (D1733) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 2 protein resulting from cleavage adjacent to D1733.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Immunogen Type    peptide
 Immunogen Description    Synthesized peptide derived from the Internal region of human Notch 2.
 Target Name    Cleaved-Notch 2
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-NOTCH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NOTCH2 antibody    Total protein Ab
 Applications Tested/Suitable for anti-NOTCH2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-NOTCH2 antibody    Western Blot: 1:500 - 1:2000
Immunohistochemistry: 1:100 - 1:300
ELISA: 1:40000
Not yet tested in other applications.
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 Western Blot (WB) of anti-NOTCH2 antibody    Western Blot analysis of 293 cells using Cleaved-Notch 2 (D1733) Polyclonal Antibody
anti-NOTCH2 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-NOTCH2 antibody    Western Blot analysis of KB cells using Cleaved-Notch 2 (D1733) Polyclonal Antibody
anti-NOTCH2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NOTCH2. It may not necessarily be applicable to this product.
 NCBI GI #    317008611
 NCBI GeneID    4853
 NCBI Accession #    NP_001186930.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001200001.1 [Other Products]
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 UniProt Primary Accession #    Q04721 [Other Products]
 UniProt Secondary Accession #    Q5T3X7; Q99734; Q9H240 [Other Products]
 UniProt Related Accession #    Q04721 [Other Products]
 Molecular Weight    265,405 Da [Similar Products]
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 NCBI Official Full Name    neurogenic locus notch homolog protein 2 isoform 2
 NCBI Official Synonym Full Names    notch 2
 NCBI Official Symbol    NOTCH2 [Similar Products]
 NCBI Official Synonym Symbols   
hN2; AGS2; HJCYS
[Similar Products]
 NCBI Protein Information    neurogenic locus notch homolog protein 2
 UniProt Protein Name    Neurogenic locus notch homolog protein 2
 Protein Family    Neurogenic locus notch homolog protein
 UniProt Gene Name    NOTCH2 [Similar Products]
 UniProt Synonym Gene Names    N2ICD [Similar Products]
 UniProt Entry Name    NOTC2_HUMAN
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 NCBI Summary for NOTCH2    This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
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 UniProt Comments for NOTCH2    Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus.

Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13-p11

Cellular Component: Golgi membrane; nucleoplasm; endoplasmic reticulum membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; extracellular region; nucleus; receptor complex; cilium

Molecular Function: protein binding; receptor activity; calcium ion binding

Biological Process: apoptosis; positive regulation of apoptosis; multicellular organismal development; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; bone remodeling; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; morphogenesis of an epithelial sheet; hemopoiesis; cell cycle arrest; cell growth; positive regulation of BMP signaling pathway; embryonic limb morphogenesis; transcription initiation from RNA polymerase II promoter; nervous system development; Notch signaling pathway; intracellular receptor-mediated signaling pathway; in utero embryonic development; stem cell maintenance; Notch receptor processing; humoral immune response; organ morphogenesis; inflammatory response to antigenic stimulus; defense response to bacterium; gene expression; positive regulation of Ras protein signal transduction; determination of left/right symmetry; negative regulation of apoptosis

Disease: Hajdu-cheney Syndrome; Alagille Syndrome 2
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 Research Articles on NOTCH2    1. Its signaling pathway determines pathological aggressiveness of intra ductal papillary mucinous neoplasm of the pancreas.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NOTCH2 antibodyPathways associated with anti-NOTCH2 antibody
 Reference Product  PubMed Publications
 HES1 antibody  >111 publications with NOTCH2 and HES1
 HEY1 antibody  >37 publications with NOTCH2 and HEY1
 RBPJ antibody  >32 publications with NOTCH2 and RBPJ
 TP53 antibody  >19 publications with NOTCH2 and TP53
 LFNG antibody  >12 publications with NOTCH2 and LFNG
 NUMB antibody  >9 publications with NOTCH2 and NUMB
 DTX1 antibody  >5 publications with NOTCH2 and DTX1
 WNT1 antibody  >3 publications with NOTCH2 and WNT1
 PSEN2 antibody  >3 publications with NOTCH2 and PSEN2
 PSEN1 antibody  >3 publications with NOTCH2 and PSEN1
 Products by Pathway  Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 NOTCH2 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH2 Intracellular Domain Regulates Transcription Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
Diseases associated with anti-NOTCH2 antibodyOrgans/Tissues associated with anti-NOTCH2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >57 publications with NOTCH2 and Cardiovascular Diseases
 Alagille Syndrome Antibodies  >43 publications with NOTCH2 and Alagille Syndrome
 Liver Diseases Antibodies  >43 publications with NOTCH2 and Liver Diseases
 Disease Models, Animal Antibodies  >33 publications with NOTCH2 and Disease Models, Animal
 Diabetes Mellitus, Type 2 Antibodies  >29 publications with NOTCH2 and Diabetes Mellitus, Type 2
 Breast Neoplasms Antibodies  >29 publications with NOTCH2 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >26 publications with NOTCH2 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >24 publications with NOTCH2 and Neoplasms, Experimental
 Hajdu-Cheney Syndrome Antibodies  >22 publications with NOTCH2 and Hajdu-Cheney Syndrome
 Kidney Diseases Antibodies  >21 publications with NOTCH2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >143 publications with NOTCH2 and Blood
 Bone Antibodies  >103 publications with NOTCH2 and Bone
 Brain Antibodies  >83 publications with NOTCH2 and Brain
 Embryonic Tissue Antibodies  >82 publications with NOTCH2 and Embryonic Tissue
 Liver Antibodies  >80 publications with NOTCH2 and Liver
 Bone Marrow Antibodies  >54 publications with NOTCH2 and Bone Marrow
 Vascular Antibodies  >54 publications with NOTCH2 and Vascular
 Kidney Antibodies  >50 publications with NOTCH2 and Kidney
 Muscle Antibodies  >40 publications with NOTCH2 and Muscle
 Heart Antibodies  >39 publications with NOTCH2 and Heart
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