O15516
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CLOCK
NCBI Official Synonym Full Names
clock homolog (mouse)
NCBI Protein Information
circadian locomoter output cycles protein kaput; OTTHUMP00000128334; OTTHUMP00000196798; OTTHUMP00000218844; class E basic helix-loop-helix protein 8; circadian locomoter output cycles kaput protein
UniProt Protein Name
Circadian locomoter output cycles protein kaput
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 8
UniProt Synonym Gene Names
UniProt Entry Name
CLOCK_HUMAN
NCBI Summary for CLOCK
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1. [provided by RefSeq]
UniProt Comments for CLOCK
CLOCK: ARNTL/2-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. Acetylates primarily histones H3 and H4. Acetylates also a non-histone substrate: ARNTL. Plays a role in DNA damage response (DDR) signaling during the S phase. Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with ARNTL is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Binds weakly ARNTL and ARNTL2 to form heterodimers which bind poorly to the E-box motif. Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN).
Protein type: DNA-binding; Acetyltransferase; EC 2.3.1.48; Transcription factor
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: nucleoplasm; transcription factor complex; intracellular membrane-bound organelle; chromosome; cytosol; nucleus
Molecular Function: protein dimerization activity; protein binding; signal transducer activity; histone acetyltransferase activity; DNA binding; chromatin DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; establishment and/or maintenance of chromatin architecture; positive regulation of transcription, DNA-dependent; response to redox state; signal transduction; activation of NF-kappaB transcription factor; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; photoperiodism; DNA damage checkpoint; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; histone acetylation; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of hair cycle; regulation of insulin secretion; positive regulation of inflammatory response
Research Articles on CLOCK
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Products associated with anti-CLOCK antibody
Pathways associated with anti-CLOCK antibody
Diseases associated with anti-CLOCK antibody
Organs/Tissues associated with anti-CLOCK antibody
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