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anti-CLU antibody :: Rabbit anti-Human Clusterin (CLU) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2003051 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $90 +1 FREE 8GB USB
0.02 mg  /  $105 +1 FREE 8GB USB
0.05 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $170 +1 FREE 8GB USB
0.2 mg  /  $235 +1 FREE 8GB USB
1 mg  /  $545 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Clusterin (CLU), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Clusterin (CLU)

 Product Gene Name   

anti-CLU antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M25915 mRNA
 3D Structure    ModBase 3D Structure for P10909
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against CLU. It has been selected for its ability to recognize CLU in immunohistochemical staining andwestern blotting.
 Purity/Purification    Antigen-specific Affinity Chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
 Concentration    200ug/ml (lot specific)
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 Source    Polyclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant CLU (Ser228~Glu449) expressed in E.coli
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2052203
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-CLU antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CLU antibody   

WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM

 Application Notes for anti-CLU antibody    Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml

Optimal working dilutions must be determined by end user
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 Western Blot (WB) of anti-CLU antibody    (Figure. Western Blot; Sample: Human Serum Tissue.)
anti-CLU antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-CLU antibody    (Figure. Western Blot; Sample: Recombinant CLU, Human.)
anti-CLU antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CLU antibody    (Used in DAB staining on formalin fixed paraffin-embedded Liver tissue)
anti-CLU antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CLU. It may not necessarily be applicable to this product.
 NCBI GI #    355594753
 NCBI GeneID    1191
 NCBI Accession #    NP_001822.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001831.3 [Other Products]
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 UniProt Primary Accession #    P10909 [Other Products]
 UniProt Secondary Accession #    P11380; P11381; Q2TU75; Q5HYC1; Q7Z5B9; B2R9Q1; B3KSE6 [Other Products]
 UniProt Related Accession #    P10909; AAB25217 [Other Products]
 Molecular Weight    53,643 Da
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 NCBI Official Full Name    clusterin preproprotein
 NCBI Official Synonym Full Names    clusterin
 NCBI Official Symbol    CLU [Similar Products]
 NCBI Official Synonym Symbols   
CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2
[Similar Products]
 NCBI Protein Information    clusterin
 UniProt Protein Name    Clusterin
 UniProt Synonym Protein Names   
Aging-associated gene 4 protein; Apolipoprotein J; Apo-J
 Protein Family    Clusterin
 UniProt Gene Name    CLU [Similar Products]
 UniProt Synonym Gene Names    APOJ; CLI; KUB1; Apo-J; CLI; TRPM-2 [Similar Products]
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 NCBI Summary for CLU    The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
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 UniProt Comments for CLU    CLU: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. Belongs to the clusterin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Mitochondrial; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p21.1

Cellular Component: cell surface; cytoplasm; cytosol; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; intracellular; mitochondrial membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: amyloid-beta binding; ATPase activity; chaperone binding; low-density lipoprotein receptor binding; misfolded protein binding; protein binding; protein complex binding; ubiquitin protein ligase binding

Biological Process: antimicrobial humoral response; cell morphogenesis; central nervous system myelin maintenance; chaperone-mediated protein complex assembly; complement activation; complement activation, classical pathway; innate immune response; lipid metabolic process; microglial cell activation; negative regulation of protein homooligomerization; platelet degranulation; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein homooligomerization; positive regulation of receptor-mediated endocytosis; positive regulation of tumor necrosis factor production; protein import; protein stabilization; regulation of complement activation; release of cytochrome c from mitochondria; response to misfolded protein; response to virus; reverse cholesterol transport
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 Research Articles on CLU    1. data confirm that the association of psoriatic disease with some comorbidities, especially metabolic and cardiovascular disease, might support the correlation with increased circulating Clu.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLU antibodyPathways associated with anti-CLU antibody
 Reference Product  PubMed Publications
 APP antibody  >14 publications with CLU and APP
 PON1 antibody  >10 publications with CLU and PON1
 PRNP antibody  >4 publications with CLU and PRNP
 MMP25 antibody  >1 publications with CLU and MMP25
 TGFBR2 antibody  >1 publications with CLU and TGFBR2
 CLUAP1 antibody  >1 publications with CLU and CLUAP1
 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
Diseases associated with anti-CLU antibodyOrgans/Tissues associated with anti-CLU antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >272 publications with CLU and Neoplasms
 Nervous System Diseases Antibodies  >171 publications with CLU and Nervous System Diseases
 Alzheimer Disease Antibodies  >119 publications with CLU and Alzheimer Disease
 Prostatic Neoplasms Antibodies  >82 publications with CLU and Prostatic Neoplasms
 Kidney Diseases Antibodies  >54 publications with CLU and Kidney Diseases
 Cardiovascular Diseases Antibodies  >53 publications with CLU and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >46 publications with CLU and Breast Neoplasms
 Necrosis Antibodies  >46 publications with CLU and Necrosis
 Inflammation Antibodies  >43 publications with CLU and Inflammation
 Adenocarcinoma Antibodies  >42 publications with CLU and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >230 publications with CLU and Blood
 Brain Antibodies  >154 publications with CLU and Brain
 Prostate Antibodies  >123 publications with CLU and Prostate
 Nerve Antibodies  >75 publications with CLU and Nerve
 Kidney Antibodies  >73 publications with CLU and Kidney
 Vascular Antibodies  >64 publications with CLU and Vascular
 Liver Antibodies  >62 publications with CLU and Liver
 Eye Antibodies  >45 publications with CLU and Eye
 Testis Antibodies  >42 publications with CLU and Testis
 Muscle Antibodies  >35 publications with CLU and Muscle
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