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anti-CLU antibody :: Rabbit anti-Human Clusterin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150150
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Clusterin, Polyclonal Antibody

★Popular Item★
 Also Known As   

Clusterin Antibody

 Product Synonym Names    Clusterin; CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2; CLI; Clusterin; Aging-associated gene 4 protein; Apo-J; clusterin
 Product Gene Name   

anti-CLU antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    185430
 3D Structure    ModBase 3D Structure for P10909
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Clusterin Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    Clusterin antibody was raised recombinant human Clusterin isoform 1.
 Buffer    Clusterin Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    Clusterin antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-CLU antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CLU antibody

   Clusterin Antibody: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide. Clusterin expression is increased in Alzheimer's disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression. Clusterin exists in at least two distinct isoforms.
 Applications Tested/Suitable for anti-CLU antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CLU antibody    Clusterin antibody can be used for the detection of Clusterin by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL.
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 Western Blot (WB) of anti-CLU antibody    Western blot analysis of Clusterin in human brain tissue lysate with Clusterin body at (A) 0.5 and (B) 1 μg/mL.
anti-CLU antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CLU antibody    Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 10 μg/mL.
anti-CLU antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CLU. It may not necessarily be applicable to this product.
 NCBI GI #    42716297
 NCBI GeneID    1191
 NCBI Accession #    NP_001822 [Other Products]
 NCBI GenBank Nucleotide #    NM_001831.2 [Other Products]
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 UniProt Primary Accession #    P10909 [Other Products]
 UniProt Secondary Accession #    P11380; P11381; Q2TU75; Q5HYC1; Q7Z5B9; B2R9Q1; B3KSE6 [Other Products]
 UniProt Related Accession #    P10909; AAB25217 [Other Products]
 Molecular Weight    53,643 Da
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 NCBI Official Full Name    clusterin isoform 1
 NCBI Official Synonym Full Names    clusterin
 NCBI Official Symbol    CLU [Similar Products]
 NCBI Official Synonym Symbols   
CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2
[Similar Products]
 NCBI Protein Information    clusterin; apolipoprotein J; ku70-binding protein 1; sulfated glycoprotein 2; aging-associated protein 4; complement lysis inhibitor; complement cytolysis inhibitor; complement-associated protein SP-40,40; testosterone-repressed prostate message 2
 UniProt Protein Name    Clusterin
 UniProt Synonym Protein Names   
Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; Testosterone-repressed prostate message 2; TRPM-2
 Protein Family    Clusterin
 UniProt Gene Name    CLU [Similar Products]
 UniProt Synonym Gene Names    APOJ; CLI; KUB1; Apo-J; CLI; TRPM-2 [Similar Products]
 UniProt Entry Name    CLUS_HUMAN
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 NCBI Summary for CLU    The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
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 UniProt Comments for CLU    CLU: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. Belongs to the clusterin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Mitochondrial; Apoptosis

Chromosomal Location of Human Ortholog: 8p21-p12

Cellular Component: extracellular matrix; Golgi apparatus; extracellular space; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; mitochondrial membrane; cytoplasm; extracellular region; cytosol; nucleus

Molecular Function: protein binding; ubiquitin protein ligase binding; chaperone binding; ATPase activity; misfolded protein binding

Biological Process: platelet activation; response to misfolded protein; release of cytochrome c from mitochondria; positive regulation of nitric oxide biosynthetic process; protein stabilization; positive regulation of apoptosis; response to virus; cell morphogenesis; microglial cell activation; positive regulation of tumor necrosis factor production; activation of NF-kappaB transcription factor; negative regulation of protein homooligomerization; complement activation; reverse cholesterol transport; platelet degranulation; myelin maintenance in the central nervous system; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein import; innate immune response; lipid metabolic process; chaperone-mediated protein complex assembly; blood coagulation; complement activation, classical pathway
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 Research Articles on CLU    1. Results show that that nuclear CLU expression is regulated by direct binding of HIF-1alpha to hypoxia response elements sites and is epigenetically controlled by methylation of its promoter region.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLU antibodyPathways associated with anti-CLU antibody
 Reference Product  PubMed Publications
 APP antibody  >20 publications with CLU and APP
 TGFB1 antibody  >16 publications with CLU and TGFB1
 EGF antibody  >14 publications with CLU and EGF
 UBC antibody  >6 publications with CLU and UBC
 FN1 antibody  >2 publications with CLU and FN1
 VHL antibody  >1 publications with CLU and VHL
 ALB antibody  >1 publications with CLU and ALB
 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
Diseases associated with anti-CLU antibodyOrgans/Tissues associated with anti-CLU antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >201 publications with CLU and Nervous System Diseases
 Brain Diseases Antibodies  >182 publications with CLU and Brain Diseases
 Alzheimer Disease Antibodies  >150 publications with CLU and Alzheimer Disease
 Prostatic Neoplasms Antibodies  >88 publications with CLU and Prostatic Neoplasms
 Kidney Diseases Antibodies  >62 publications with CLU and Kidney Diseases
 Cardiovascular Diseases Antibodies  >59 publications with CLU and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >55 publications with CLU and Disease Models, Animal
 Adenocarcinoma Antibodies  >51 publications with CLU and Adenocarcinoma
 Necrosis Antibodies  >51 publications with CLU and Necrosis
 Breast Neoplasms Antibodies  >48 publications with CLU and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >255 publications with CLU and Blood
 Brain Antibodies  >186 publications with CLU and Brain
 Prostate Antibodies  >131 publications with CLU and Prostate
 Kidney Antibodies  >88 publications with CLU and Kidney
 Nerve Antibodies  >80 publications with CLU and Nerve
 Liver Antibodies  >70 publications with CLU and Liver
 Vascular Antibodies  >70 publications with CLU and Vascular
 Eye Antibodies  >46 publications with CLU and Eye
 Testis Antibodies  >45 publications with CLU and Testis
 Muscle Antibodies  >36 publications with CLU and Muscle
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