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anti-COTL1 antibody :: Rabbit anti-Human Coactosin Like Protein 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2026807 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Coactosin Like Protein 1 (COTL1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Coactosin Like Protein 1 (COTL1)

 Product Gene Name   

anti-COTL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    L54057 mRNA
 3D Structure    ModBase 3D Structure for Q14019
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against COTL1. It has beenselected for its ability to recognize COTL1 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    COTL1 (Met1~Glu142)
 Organism Species    Homo sapiens (Human)
 Conjugate    No Conjugate
 Immunogen    Recombinant COTL1 (Met1~Glu142) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2081254
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-COTL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-COTL1 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-COTL1 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-COTL1 antibody    Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) Knockout Verification of anti-COTL1 antibody    Knockout Verification: Lane 1: Wild-type Hela cell lysate; Lane 2: COTL1 knockout Hela cell lysate; Predicted MW: 16kd Observed MW: 16kd Primary Ab: 1ug/ml Rabbit Anti-Human COTL1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-COTL1 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-COTL1 antibody    Western Blot; Sample: Lane1: Human Lung Tissue; Lane2: Human Hela Cells; Lane3: Mouse Placenta Tissue; Lane4: Mouse Kidney Tissue.
anti-COTL1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-COTL1 antibody    Western Blot ; Sample: Recombinant COTL1, Human.
anti-COTL1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-COTL1 antibody    DAB staining on IHC-P; Samples: Human Glioma Tissue.
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-COTL1 antibody    DAB staining on IHC-P; Samples: Human Kidney Tissue
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-COTL1 antibody    DAB staining on IHC-P; Samples: Human Prostate Gland Tissue
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-COTL1 antibody    FITC staining on IHC-P Simple: Hela cells)
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-COTL1 antibody    DAB staining on IHC-P; Samples: Human Breast Cancer Tissue
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for COTL1. It may not necessarily be applicable to this product.
 NCBI GI #    21624607
 NCBI GeneID    23406
 NCBI Accession #    NP_066972.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021149.3 [Other Products]
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 UniProt Primary Accession #    Q14019 [Other Products]
 UniProt Secondary Accession #    Q86XM5; B2RDU3; D3DUL9 [Other Products]
 UniProt Related Accession #    Q14019 [Other Products]
 Molecular Weight    15,945 Da
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 NCBI Official Full Name    coactosin-like protein
 NCBI Official Synonym Full Names    coactosin like F-actin binding protein 1
 NCBI Official Symbol    COTL1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    coactosin-like protein
 UniProt Protein Name    Coactosin-like protein
 Protein Family    Coactosin-like protein
 UniProt Gene Name    COTL1 [Similar Products]
 UniProt Synonym Gene Names    CLP [Similar Products]
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 NCBI Summary for COTL1    This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for COTL1    COTL1: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Belongs to the actin-binding proteins ADF family. Coactosin subfamily.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytoskeleton; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; nucleus; secretory granule lumen

Molecular Function: actin binding; enzyme binding; protein binding

Biological Process: defense response to fungus; neutrophil degranulation
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 Research Articles on COTL1    1. The roles of CLP and FLAP in in cellular leukotriene biosynthesis, were studied.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-COTL1 antibodyOrgans/Tissues associated with anti-COTL1 antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >4 publications with COTL1 and Lung Diseases
 Lung Neoplasms Antibodies  >3 publications with COTL1 and Lung Neoplasms
 Inflammation Antibodies  >2 publications with COTL1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with COTL1 and Blood
 Lung Antibodies  >6 publications with COTL1 and Lung
 Kidney Antibodies  >2 publications with COTL1 and Kidney
 Liver Antibodies  >1 publications with COTL1 and Liver
 Embryonic Tissue Antibodies  >1 publications with COTL1 and Embryonic Tissue
 Placenta Antibodies  >1 publications with COTL1 and Placenta
 Brain Antibodies  >1 publications with COTL1 and Brain
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