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anti-COL3A1 antibody :: Collagen 3 alpha 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS822102
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen 3 alpha 1 (COL3A1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Collagen 3 alpha 1 Antibody

 Product Synonym Names    Collagen alpha-1(III) chain
 Product Gene Name   

anti-COL3A1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Collagen 3 alpha 1 peptide (MBS823151) is used for blocking the activity of Collagen 3 alpha 1 antibody (MBS822102)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 130050
 3D Structure    ModBase 3D Structure for P02461
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 Clonality    Polyclonal
 Species Reactivity    Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit
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 Specificity    Recognizes endogenous levels of Collagen 3 alpha 1 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Source    Rabbit
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Collagen 3 alpha 1. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4C. Upon delivery aliquot and store at -20C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-COL3A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-COL3A1 antibody

   Rabbit polyclonal antibody to Collagen 3 alpha 1
 Application Notes for anti-COL3A1 antibody    WB 1/500 - 1/1000
IH 1/100 - 1/200
IF/IC 1/100 - 1/500
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 Western Blot (WB) of anti-COL3A1 antibody    Western blot analysis of Collagen 3 alpha 1 expression in A10 (A), HeLa (B), mouse lung (C), mouse liver (D), rat lung (E) whole cell lysates.
anti-COL3A1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-COL3A1 antibody    Immunohistochemical analysis of Collagen 3 alpha 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-COL3A1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence/Immunocytochemistry (IF/ICC) of anti-COL3A1 antibody    Immunofluorescent analysis of Collagen 3 alpha 1 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-COL3A1 antibody Immunofluorescence/Immunocytochemistry (IF/ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for COL3A1. It may not necessarily be applicable to this product.
 NCBI GI #    4502951
 NCBI GeneID    1281
 NCBI Accession #    NP_000081.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000090.3 [Other Products]
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 UniProt Primary Accession #    P02461 [Other Products]
 UniProt Secondary Accession #    P78429; Q15112; Q16403; Q53S91; Q541P8; Q6LDB3; Q6LDJ2; Q6LDJ3; Q7KZ56; D2JYH5; D3DPH4 [Other Products]
 UniProt Related Accession #    P02461 [Other Products]
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 NCBI Official Full Name    collagen alpha-1(III) chain preproprotein
 NCBI Official Synonym Full Names    collagen, type III, alpha 1
 NCBI Official Symbol    COL3A1 [Similar Products]
 NCBI Official Synonym Symbols   
EDS4A
[Similar Products]
 NCBI Protein Information    collagen alpha-1(III) chain; collagen alpha-1(III) chain; collagen, fetal; alpha1 (III) collagen; Ehlers-Danlos syndrome type IV, autosomal dominant
 UniProt Protein Name    Collagen alpha-1(III) chain
 Protein Family    Collagen
 UniProt Gene Name    COL3A1 [Similar Products]
 UniProt Entry Name    CO3A1_HUMAN
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 NCBI Summary for COL3A1    This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
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 UniProt Comments for COL3A1    CO3A1: Collagen type III occurs in most soft connective tissues along with type I collagen. Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3); also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA). AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. Belongs to the fibrillar collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Cell adhesion; Extracellular matrix

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen type III

Molecular Function: integrin binding; protein binding; platelet-derived growth factor binding; extracellular matrix structural constituent; metal ion binding; SMAD binding

Biological Process: integrin-mediated signaling pathway; skin development; axon guidance; platelet activation; receptor-mediated endocytosis; extracellular matrix organization and biogenesis; collagen fibril organization; wound healing; heart development; cell-matrix adhesion; negative regulation of immune response; positive regulation of Rho protein signal transduction; extracellular matrix disassembly; collagen catabolic process; response to radiation; gut development; response to mechanical stimulus; response to cytokine stimulus; transforming growth factor beta receptor signaling pathway; fibril organization and biogenesis; cerebral cortex development; peptide cross-linking; skeletal development; aging

Disease: Ehlers-danlos Syndrome, Type Iv, Autosomal Dominant; Ehlers-danlos Syndrome, Type Iii
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 Research Articles on COL3A1    1. results suggest that mitofusin-2 protein may affect the synthesis of procollagen of fibroblasts in postmenopausal patients with pelvic organ prolapse (POP); changes in Mfn2 and procollagen expression may play a role in the development of POP
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-COL3A1 antibodyDiseases associated with anti-COL3A1 antibody
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >194 publications with COL3A1 and Cardiovascular Diseases
 Ehlers-Danlos Syndrome Antibodies  >167 publications with COL3A1 and Ehlers-Danlos Syndrome
 Fibrosis Antibodies  >84 publications with COL3A1 and Fibrosis
 Disease Models, Animal Antibodies  >36 publications with COL3A1 and Disease Models, Animal
 Inflammation Antibodies  >35 publications with COL3A1 and Inflammation
 Heart Diseases Antibodies  >29 publications with COL3A1 and Heart Diseases
 Hypertension Antibodies  >15 publications with COL3A1 and Hypertension
 Hypertrophy Antibodies  >13 publications with COL3A1 and Hypertrophy
 Necrosis Antibodies  >12 publications with COL3A1 and Necrosis
 Liver Diseases Antibodies  >9 publications with COL3A1 and Liver Diseases
Organs/Tissues associated with anti-COL3A1 antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >139 publications with COL3A1 and Vascular
 Connective Tissue Antibodies  >110 publications with COL3A1 and Connective Tissue
 Skin Antibodies  >109 publications with COL3A1 and Skin
 Blood Antibodies  >85 publications with COL3A1 and Blood
 Muscle Antibodies  >83 publications with COL3A1 and Muscle
 Bone Antibodies  >48 publications with COL3A1 and Bone
 Heart Antibodies  >42 publications with COL3A1 and Heart
 Lung Antibodies  >36 publications with COL3A1 and Lung
 Kidney Antibodies  >18 publications with COL3A1 and Kidney
 Uterus Antibodies  >16 publications with COL3A1 and Uterus
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