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anti-COL1A1 antibody :: Rabbit Collagen I Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176170 anti-COL1A1 antibody
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 Product Name   

Collagen I (COL1A1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Collagen I antibody

 Product Synonym Names    Collagen alpha-1(I) chain; collagen, type I, alpha 1; Alpha 1 type I collagen antibody; Alpha 2 type I collagen antibody; Alpha-1 type I collagen antibody; CO1A1_HUMAN antibody; COL1A1 antibody; COL1A2 antibody; Collagen alpha-1(I) chain antibody; Collagen I alpha 1 polypeptide antibody; Collagen I alpha 2 polypeptide antibody; Collagen Of Skin Tendon And Bone antibody; Collagen Type 1 antibody; Collagen type I alpha 1 antibody; Collagen type I alpha 2 antibody; OI4 antibody; Osteogenesis Imperfecta Type IV antibody; Pro alpha 1(I) collagen antibody; Type I procollagen antibody
 Product Gene Name   

anti-COL1A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607907
 3D Structure    ModBase 3D Structure for P02452
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen I (1203-1218aa QPPQEKAHDGGRYYRA), different from the related rat and mouse sequences by two amino acids.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-COL1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-COL1A1 antibody

   Description: Rabbit IgG polyclonal antibody for Collagen alpha-1(I) chain(COL1A1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.
Background: Collagen, type I, alpha 1, also known as COL1A1, is a human gene that encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. This gene is mapped to 17q21.33. This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis.
 Applications Tested/Suitable for anti-COL1A1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry (ICC)

 Application Notes for anti-COL1A1 antibody    Western Blot:
Concentration:0.1-0.5ug/ml
Tested Species: Rat
Predicted Species: Hu, Ms
Immunohistochemistry (Paraffin-embedded Section):
Concentration:0.5-1 ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms
Antigen Retrieval: By Heat
Immunohistochemistry (Frosen Section)
Concentration: 0.5-1ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms
Immunocytochemistry:
Concentration:0.5-1ug/ml
Tested Species: Ms
Predicted Species: Hu,Rat

WB: The detection limit for COL1A1 is approximately 0.5ng/lane under reducing conditions.
Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 100mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
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NCBI/Uniprot data below describe general gene information for COL1A1. It may not necessarily be applicable to this product.
 NCBI GI #    296439504
 NCBI GeneID    1277
 NCBI Accession #    P02452.5 [Other Products]
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 UniProt Primary Accession #    P02452 [Other Products]
 UniProt Secondary Accession #    O76045; P78441; Q13896; Q13902; Q13903; Q14037; Q14992; Q15176; Q15201; Q16050; Q59F64 [Other Products]
 UniProt Related Accession #    P02452 [Other Products]
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 NCBI Official Full Name    Collagen alpha-1(I) chain
 NCBI Official Synonym Full Names    collagen, type I, alpha 1
 NCBI Official Symbol    COL1A1 [Similar Products]
 NCBI Official Synonym Symbols   
OI4
[Similar Products]
 NCBI Protein Information    collagen alpha-1(I) chain; collagen alpha-1(I) chain; alpha-1 type I collagen; pro-alpha-1 collagen type 1; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain
 UniProt Protein Name    Collagen alpha-1(I) chain
 UniProt Synonym Protein Names   
Alpha-1 type I collagen
 Protein Family    Collagen
 UniProt Gene Name    COL1A1 [Similar Products]
 UniProt Entry Name    CO1A1_HUMAN
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 NCBI Summary for COL1A1    This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
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 UniProt Comments for COL1A1    COL1A1: Type I collagen is a member of group I collagen (fibrillar forming collagen). Defects in COL1A1 are the cause of Caffey disease (CAFFD); also known as infantile cortical hyperostosis. Caffey disease is characterized by an infantile episode of massive subperiosteal new bone formation that typically involves the diaphyses of the long bones, mandible, and clavicles. The involved bones may also appear inflamed, with painful swelling and systemic fever often accompanying the illness. The bone changes usually begin before 5 months of age and resolve before 2 years of age. Defects in COL1A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL1A1 are the cause of Ehlers-Danlos syndrome type 7A (EDS7A); also known as autosomal dominant Ehlers-Danlos syndrome type VII. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7A is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. Defects in COL1A1 are a cause of osteogenesis imperfecta type 1 (OI1). A dominantly inherited connective tissue disorder characterized by bone fragility and blue sclerae. Osteogenesis imperfecta type 1 is non-deforming with normal height or mild short stature, and no dentinogenesis imperfecta. Defects in COL1A1 are a cause of osteogenesis imperfecta type 2 (OI2); also known as osteogenesis imperfecta congenita. A connective tissue disorder characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency. Defects in COL1A1 are a cause of osteogenesis imperfecta type 3 (OI3). A connective tissue disorder characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera, and dentinogenesis imperfecta. Defects in COL1A1 are a cause of osteogenesis imperfecta type 4 (OI4); also known as osteogenesis imperfecta with normal sclerae. A connective tissue disorder characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta. Genetic variations in COL1A1 are a cause of susceptibility to osteoporosis (OSTEOP); also known as involutional or senile osteoporosis or postmenopausal osteoporosis. Osteoporosis is characterized by reduced bone mass, disruption of bone microarchitecture without alteration in the composition of bone. Osteoporotic bones are more at risk of fracture. A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF. Belongs to the fibrillar collagen family.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: Golgi apparatus; extracellular matrix; extracellular space; endoplasmic reticulum lumen; collagen type I; extracellular region; secretory granule

Molecular Function: identical protein binding; protein binding; platelet-derived growth factor binding; metal ion binding; extracellular matrix structural constituent

Biological Process: response to peptide hormone stimulus; extracellular matrix organization and biogenesis; intramembranous ossification; collagen fibril organization; response to cAMP; positive regulation of transcription, DNA-dependent; embryonic skeletal development; response to estradiol stimulus; response to corticosteroid stimulus; extracellular matrix disassembly; protein transport; sensory perception of sound; visual perception; collagen biosynthetic process; skeletal development; endochondral ossification; response to drug; blood vessel development; platelet activation; receptor-mediated endocytosis; skin morphogenesis; osteoblast differentiation; collagen catabolic process; response to hyperoxia; response to hydrogen peroxide; blood coagulation; leukocyte migration; positive regulation of cell migration

Disease: Osteogenesis Imperfecta, Type I; Ehlers-danlos Syndrome, Type Vii, Autosomal Dominant; Osteogenesis Imperfecta, Type Ii; Ehlers-danlos Syndrome, Type I; Osteogenesis Imperfecta, Type Iii; Osteoporosis; Caffey Disease; Osteogenesis Imperfecta, Type Iv
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 Research Articles on COL1A1    1. IL-13 potentiates airway remodelling through a mechanism involving collagen type I expression, TGF-beta1 and MMP-2
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-COL1A1 antibodyDiseases associated with anti-COL1A1 antibody
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Disease Name  Pubmed Publications
 Osteogenesis Imperfecta Antibodies  >282 publications with COL1A1 and Osteogenesis Imperfecta
 Fibrosis Antibodies  >182 publications with COL1A1 and Fibrosis
 Osteoporosis Antibodies  >121 publications with COL1A1 and Osteoporosis
 Disease Models, Animal Antibodies  >89 publications with COL1A1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >78 publications with COL1A1 and Cardiovascular Diseases
 Inflammation Antibodies  >66 publications with COL1A1 and Inflammation
 Liver Diseases Antibodies  >44 publications with COL1A1 and Liver Diseases
 Heart Diseases Antibodies  >35 publications with COL1A1 and Heart Diseases
 Necrosis Antibodies  >32 publications with COL1A1 and Necrosis
 Liver Cirrhosis Antibodies  >27 publications with COL1A1 and Liver Cirrhosis
Organs/Tissues associated with anti-COL1A1 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >584 publications with COL1A1 and Bone
 Connective Tissue Antibodies  >251 publications with COL1A1 and Connective Tissue
 Skin Antibodies  >231 publications with COL1A1 and Skin
 Muscle Antibodies  >134 publications with COL1A1 and Muscle
 Blood Antibodies  >133 publications with COL1A1 and Blood
 Bone Marrow Antibodies  >95 publications with COL1A1 and Bone Marrow
 Vascular Antibodies  >76 publications with COL1A1 and Vascular
 Liver Antibodies  >75 publications with COL1A1 and Liver
 Lung Antibodies  >65 publications with COL1A1 and Lung
 Heart Antibodies  >50 publications with COL1A1 and Heart
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