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anti-COL1A1 antibody :: Rabbit anti-Fish Collagen Type I Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS316323 anti-COL1A1 antibody
Unit / Price
0.5 mL  /  $985 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen Type I (COL1A1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit A' Fish Collagen Type I

 Product Synonym Names    Rabbit Antibody to Fish Collagen Type I
 Product Gene Name   

anti-COL1A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (48261457..48279000, complement). Location: 17q21.33
 OMIM    114000
 3D Structure    ModBase 3D Structure for P02452
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Fish
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 Specificity    Collagen Type I
Crossreactivity: (OD at a 1:100 ELISA dilution)Salmon Fish Collagen Type I - 1.0Sole and Tuna fish Collagen Type I - <0.4Goldfish Collagen Type I - <0.2*Mammalian, avian Collagen Type I - <0.2*(*OD?0.2 means negative reac
 Purity/Purification    Ion exchange chromatography
 Form/Format    Purified, Lyophilized
Reconstitute with 0.5ml deionized water.
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 Immunogen    Collagen Type I extracted and purified from salmon fish skin
 Buffer    Not applicable
 Preservative    No
 Lyophilized    Yes
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
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 Preparation and Storage    Lyophilized: Short-term (up to 24 months) store at 2 to 8 degree C. Long term store at -20 degree C.
Reconstituted: Aliquot and store (up to 6 months) at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-COL1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-COL1A1 antibody    Polyclonal Antibodies to Collagens and Extracellular Matrix Proteins
NCBI/Uniprot data below describe general gene information for COL1A1. It may not necessarily be applicable to this product.
 NCBI GI #    119615037
 NCBI GeneID    1277
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 UniProt Primary Accession #    P02452 [Other Products]
 UniProt Secondary Accession #    O76045; P78441; Q13896; Q13902; Q13903; Q14037; Q14992; Q15176; Q15201; Q16050; Q59F64 [Other Products]
 UniProt Related Accession #    P02452; Q14042; Q6LAN8; Q9UMA6 [Other Products]
 Molecular Weight    138,941 Da [Similar Products]
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 NCBI Official Full Name    collagen, type I, alpha 1, isoform CRA_a
 NCBI Official Synonym Full Names    collagen, type I, alpha 1
 NCBI Official Symbol    COL1A1 [Similar Products]
 NCBI Official Synonym Symbols   
OI4
[Similar Products]
 NCBI Protein Information    collagen alpha-1(I) chain; collagen alpha-1(I) chain; OTTHUMP00000192905; alpha-1 type I collagen; pro-alpha-1 collagen type 1; collagen alpha 1 chain type I; collagen of skin, tendon and bone, alpha-1 chain
 UniProt Protein Name    Collagen alpha-1(I) chain
 UniProt Synonym Protein Names   
Alpha-1 type I collagen
 Protein Family    Collagen
 UniProt Gene Name    COL1A1 [Similar Products]
 UniProt Entry Name    CO1A1_HUMAN
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 NCBI Summary for COL1A1    This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]
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 UniProt Comments for COL1A1    Function: Type I collagen is a member of group I collagen (fibrillar forming collagen).

Subunit structure: Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2

By similarity. Interacts with TRAM2. Ref.33

Subcellular location: Secreted › extracellular space › extracellular matrix

Tissue specificity: Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Post-translational modification: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some of the chains.O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.

Involvement in disease: Defects in COL1A1 are the cause of Caffey disease (CAFFD) [

MIM:114000]; also known as infantile cortical hyperostosis. Caffey disease is characterized by an infantile episode of massive subperiosteal new bone formation that typically involves the diaphyses of the long bones, mandible, and clavicles. The involved bones may also appear inflamed, with painful swelling and systemic fever often accompanying the illness. The bone changes usually begin before 5 months of age and resolve before 2 years of age. Ref.89 Ref.90 Ref.91Defects in COL1A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [

MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Ref.88 Ref.89 Ref.90 Ref.97Defects in COL1A1 are the cause of Ehlers-Danlos syndrome type 7A (EDS7A) [

MIM:130060]; also known as autosomal dominant Ehlers-Danlos syndrome type VII. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7A is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. Ref.89 Ref.90Defects in COL1A1 are a cause of osteogenesis imperfecta type 1 (OI1) [

MIM:166200]. A dominantly inherited connective tissue disorder characterized by bone fragility and blue sclerae. Osteogenesis imperfecta type 1 is non-deforming with normal height or mild short stature, and no dentinogenesis imperfecta. Ref.38 Ref.44 Ref.55 Ref.59 Ref.62 Ref.68 Ref.89 Ref.90 Ref.93 Ref.94 Ref.96 Ref.99 Ref.101Defects in COL1A1 are a cause of osteogenesis imperfecta type 2A (OI2A) [

MIM:166210]; also known as osteogenesis imperfecta congenita. A connective tissue disorder characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency.Defects in COL1A1 are a cause of osteogenesis imperfecta type 3 (OI3) [

MIM:259420]. A connective tissue disorder characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera, and dentinogenesis imperfecta.Defects in COL1A1 are a cause of osteogenesis imperfecta type 4 (OI4) [

MIM:166220]; also known as osteogenesis imperfecta with normal sclerae. A connective tissue disorder characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta.Genetic variations in COL1A1 are a cause of susceptibility to osteoporosis (OSTEOP) [

MIM:166710]; also known as involutional or senile osteoporosis or postmenopausal osteoporosis. Osteoporosis is characterized by reduced bone mass, disruption of bone microarchitecture without alteration in the composition of bone. Osteoporotic bones are more at risk of fracture. Ref.81 Ref.86 Ref.89 Ref.90Note=A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF. Ref.89 Ref.90

Sequence similarities: Belongs to the fibrillar collagen family.Contains 1 fibrillar collagen NC1 domain.Contains 1 VWFC domain.

Sequence caution: The sequence BAD92834.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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 Research Articles on COL1A1    1. The aim of this study was to analyze the relationship between COLIA1 gene polymorphism and BMD in Serbian women.The presence of the T allele in the genotype has no influence on BMD in osteoporotic group.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COL1A1 antibodyPathways associated with anti-COL1A1 antibody
 Reference Product  PubMed Publications
 PDGFB antibody  >79 publications with COL1A1 and PDGFB
 SPARC antibody  >22 publications with COL1A1 and SPARC
 MMP2 antibody  >17 publications with COL1A1 and MMP2
 FN1 antibody  >14 publications with COL1A1 and FN1
 MMP9 antibody  >12 publications with COL1A1 and MMP9
 DCN antibody  >8 publications with COL1A1 and DCN
 COL7A1 antibody  >6 publications with COL1A1 and COL7A1
 CD44 antibody  >6 publications with COL1A1 and CD44
 IGFBP3 antibody  >5 publications with COL1A1 and IGFBP3
 BGN antibody  >5 publications with COL1A1 and BGN
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Collagen Adhesion Via GPVI Pathway antibodies  Collagen Adhesion Via GPVI Pathway Diagram
 Collagen Adhesion Via Gp IV Pathway antibodies  Collagen Adhesion Via Gp IV Pathway Diagram
 Collagen Adhesion Via Alpha 2 Beta 1 Glycoprotein Pathway antibodies  Collagen Adhesion Via Alpha 2 Beta 1 Glycoprotein Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-COL1A1 antibodyOrgans/Tissues associated with anti-COL1A1 antibody
 Disease Name  Pubmed Publications
 OSTEOGENESIS IMPERFECTA, TYPE I Antibodies  >206 publications with COL1A1 and OSTEOGENESIS IMPERFECTA, TYPE I
 Skin Diseases Antibodies  >110 publications with COL1A1 and Skin Diseases
 Neoplasms Antibodies  >109 publications with COL1A1 and Neoplasms
 Fibrosis Antibodies  >96 publications with COL1A1 and Fibrosis
 Osteoporosis Antibodies  >79 publications with COL1A1 and Osteoporosis
 Fibrosarcoma Antibodies  >70 publications with COL1A1 and Fibrosarcoma
 Skin Neoplasms Antibodies  >60 publications with COL1A1 and Skin Neoplasms
 Cardiovascular Diseases Antibodies  >54 publications with COL1A1 and Cardiovascular Diseases
 Bone Resorption Antibodies  >28 publications with COL1A1 and Bone Resorption
 Inflammation Antibodies  >27 publications with COL1A1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >368 publications with COL1A1 and Bone
 Skin Antibodies  >168 publications with COL1A1 and Skin
 Connective Tissue Antibodies  >153 publications with COL1A1 and Connective Tissue
 Muscle Antibodies  >63 publications with COL1A1 and Muscle
 Bone Marrow Antibodies  >59 publications with COL1A1 and Bone Marrow
 Lung Antibodies  >39 publications with COL1A1 and Lung
 Heart Antibodies  >27 publications with COL1A1 and Heart
 Mouth Antibodies  >24 publications with COL1A1 and Mouth
 Embryonic Tissue Antibodies  >24 publications with COL1A1 and Embryonic Tissue
 Kidney Antibodies  >22 publications with COL1A1 and Kidney
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