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anti-COL3A1 antibody :: Rabbit Collagen Type III Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534144
Western Blot
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen Type III (COL3A1), Polyclonal Antibody

 Also Known As   

Collagen Type III antibody

 Product Synonym Names    Polyclonal Collagen Type III; Anti-Collagen Type III; Fetal collagen; autosomal dominant; Collagen type III alpha; Collagen type III alpha 1; EDS4A; Ehlers Danlos syndrome type IV
 Product Gene Name   

anti-COL3A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    100070
 3D Structure    ModBase 3D Structure for P02461
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bovine/Human collagen type III
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 Purity/Purification    Collagen Type III antibody was purified by affinity chromatography.
 Form/Format    Sterile filtered liquid in 0.125M Na2B4O7, pH 8.0, with 0.075M NaCl, 0.005M EDTA, and 0.01% NaN3.
 Concentration    2.0 mg/ml (lot specific)
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 Bioactivity    Some class-specific anti-collagens may be specific for three-dimensional epitopes which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin embedded tissues
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Collagen type III antibody was raised in rabbit using collagen type III from human and bovine placenta as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-COL3A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-COL3A1 antibody

   Affinity purified Rabbit polyclonal Collagen Type III antibody
 Product Categories/Family for anti-COL3A1 antibody    Cell Biology ; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-COL3A1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-COL3A1 antibody    ELISA: 1:5,000-1:10,000
IHC: 1:50-1:200
WB: 1:500-1:1,000
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 Western Blot of anti-COL3A1 antibody    Western Blot analysis using Collagen Type III antibody
Lane 1: Human Collagen III. Load: 100 ng per lane. Primary antibody: Collagen III antibody at 1:1000 ON at 4 deg C. Secondary antibody: Dylight (TM) 649 Goat anti-rabbit at 1:20, 000 for 30 min at RT. Block for 30 min at RT.
anti-COL3A1 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for COL3A1. It may not necessarily be applicable to this product.
 NCBI GI #    119631316
 NCBI GeneID    1281
 NCBI Accession #    EAX10911.1 [Other Products]
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 UniProt Primary Accession #    P02461 [Other Products]
 UniProt Secondary Accession #    P78429; Q15112; Q16403; Q53S91; Q541P8; Q6LDB3; Q6LDJ2; Q6LDJ3; Q7KZ56; D2JYH5; D3DPH4 [Other Products]
 UniProt Related Accession #    P02461 [Other Products]
 Molecular Weight    111,907 Da [Similar Products]
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 NCBI Official Full Name    collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant), isoform CRA_b
 NCBI Official Synonym Full Names    collagen, type III, alpha 1
 NCBI Official Symbol    COL3A1 [Similar Products]
 NCBI Official Synonym Symbols   
EDS4A
[Similar Products]
 NCBI Protein Information    collagen alpha-1(III) chain
 UniProt Protein Name    Collagen alpha-1(III) chain
 Protein Family    Collagen
 UniProt Gene Name    COL3A1 [Similar Products]
 UniProt Entry Name    CO3A1_HUMAN
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 NCBI Summary for COL3A1    This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
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 UniProt Comments for COL3A1    CO3A1: Collagen type III occurs in most soft connective tissues along with type I collagen. Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3); also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA). AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. Belongs to the fibrillar collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Cell adhesion; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen type III

Molecular Function: integrin binding; protein binding; metal ion binding; extracellular matrix structural constituent; platelet-derived growth factor binding; SMAD binding

Biological Process: integrin-mediated signaling pathway; skin development; platelet activation; receptor-mediated endocytosis; axon guidance; extracellular matrix organization and biogenesis; collagen fibril organization; wound healing; cell-matrix adhesion; heart development; negative regulation of immune response; positive regulation of Rho protein signal transduction; extracellular matrix disassembly; collagen catabolic process; response to radiation; gut development; response to mechanical stimulus; transforming growth factor beta receptor signaling pathway; response to cytokine stimulus; fibril organization and biogenesis; cerebral cortex development; peptide cross-linking; skeletal development; aging

Disease: Ehlers-danlos Syndrome, Type Iv, Autosomal Dominant; Ehlers-danlos Syndrome, Type Iii
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 Research Articles on COL3A1    1. rs1800255, COL3A1 2209 G>A polymorphism not associated with pelvic organ prolapse in Dutch population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COL3A1 antibodyPathways associated with anti-COL3A1 antibody
 Reference Product  PubMed Publications
 COL1A1 antibody  >207 publications with COL3A1 and COL1A1
 COL5A2 antibody  >37 publications with COL3A1 and COL5A2
 SPARC antibody  >23 publications with COL3A1 and SPARC
 COL6A1 antibody  >13 publications with COL3A1 and COL6A1
 COL12A1 antibody  >9 publications with COL3A1 and COL12A1
 COL6A2 antibody  >6 publications with COL3A1 and COL6A2
 COL15A1 antibody  >3 publications with COL3A1 and COL15A1
 COL16A1 antibody  >1 publications with COL3A1 and COL16A1
 COL8A1 antibody  >1 publications with COL3A1 and COL8A1
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with anti-COL3A1 antibodyOrgans/Tissues associated with anti-COL3A1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >201 publications with COL3A1 and Cardiovascular Diseases
 Ehlers-Danlos Syndrome Antibodies  >174 publications with COL3A1 and Ehlers-Danlos Syndrome
 Fibrosis Antibodies  >96 publications with COL3A1 and Fibrosis
 Inflammation Antibodies  >41 publications with COL3A1 and Inflammation
 Disease Models, Animal Antibodies  >39 publications with COL3A1 and Disease Models, Animal
 Heart Diseases Antibodies  >32 publications with COL3A1 and Heart Diseases
 Hypertension Antibodies  >17 publications with COL3A1 and Hypertension
 Necrosis Antibodies  >14 publications with COL3A1 and Necrosis
 Hypertrophy Antibodies  >13 publications with COL3A1 and Hypertrophy
 Liver Diseases Antibodies  >11 publications with COL3A1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >149 publications with COL3A1 and Vascular
 Connective Tissue Antibodies  >121 publications with COL3A1 and Connective Tissue
 Skin Antibodies  >117 publications with COL3A1 and Skin
 Muscle Antibodies  >93 publications with COL3A1 and Muscle
 Blood Antibodies  >88 publications with COL3A1 and Blood
 Bone Antibodies  >51 publications with COL3A1 and Bone
 Heart Antibodies  >45 publications with COL3A1 and Heart
 Lung Antibodies  >41 publications with COL3A1 and Lung
 Kidney Antibodies  >18 publications with COL3A1 and Kidney
 Uterus Antibodies  >17 publications with COL3A1 and Uterus
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