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anti-COL4A5 antibody :: Rabbit Collagen Type IV Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534314 anti-COL4A5 antibody
Unit / Price
0.25 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen Type IV (COL4A5), Polyclonal Antibody

 Also Known As   

Collagen Type IV antibody

 Product Synonym Names    Polyclonal Collagen Type IV; Anti-Collagen Type IV; Canstatin; Collagen Of Basement Membrane alpha 1 Chain; Arresten
 Product Gene Name   

anti-COL4A5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    301050
 3D Structure    ModBase 3D Structure for P29400
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 Clonality    Polyclonal
 Isotype    IgG1
 Host    Rabbit
 Species Reactivity    Cat, Dog, Fish, Human, Mouse, Pig, Rat
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 Specificity    Human collagen type IV
 Form/Format    PBS, with 1% BSA and 0.1% NaN3
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 Biological Significance    Type-IV collagen is a type of collagen found primarily in the basal lamina. The C-terminus domain is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, type-IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Collagen type IV antibody was raised in rabbit using human placenta type IV collagen as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-COL4A5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-COL4A5 antibody

   Rabbit polyclonal Collagen Type IV antibody
 Product Categories/Family for anti-COL4A5 antibody    Cancer
 Applications Tested/Suitable for anti-COL4A5 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-COL4A5 antibody    IHC: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for COL4A5. It may not necessarily be applicable to this product.
 NCBI GI #    4261609
 NCBI GeneID    1287
 NCBI Accession #    AAD13909.1 [Other Products]
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 UniProt Primary Accession #    P29400 [Other Products]
 UniProt Secondary Accession #    Q16006; Q16126; Q6LD84; Q7Z700; Q9NUB7 [Other Products]
 UniProt Related Accession #    P29400 [Other Products]
 Molecular Weight    161,632 Da [Similar Products]
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 NCBI Official Full Name    collagen type IV alpha 5 chain, partial
 NCBI Official Synonym Full Names    collagen, type IV, alpha 5
 NCBI Official Symbol    COL4A5 [Similar Products]
 NCBI Official Synonym Symbols   
ATS; ASLN; CA54
[Similar Products]
 NCBI Protein Information    collagen alpha-5(IV) chain
 UniProt Protein Name    Collagen alpha-5(IV) chain
 Protein Family    Collagen
 UniProt Gene Name    COL4A5 [Similar Products]
 UniProt Entry Name    CO4A5_HUMAN
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 NCBI Summary for COL4A5    This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
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 UniProt Comments for COL4A5    COL4A5: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A5 are the cause of Alport syndrome X- linked (APSX). APSX is characterized by progressive glomerulonephritis, renal failure, sensorineural deafness, specific eye abnormalities (lenticonous and macular flecks), and glomerular basement membrane defects. The disorder shows considerable heterogeneity in that families differ in the age of end-stage renal disease and the occurrence of deafness. Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are found in the chromosome Xq22.3 centromeric deletion syndrome. This results in a phenotype with features of diffuse leiomyomatosis and Alport syndrome (DL-ATS). Belongs to the type IV collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: endoplasmic reticulum lumen; collagen type IV; extracellular region; basal lamina; neuromuscular junction

Molecular Function: extracellular matrix structural constituent

Biological Process: axon guidance; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; neuromuscular junction development

Disease: Alport Syndrome, X-linked
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 Research Articles on COL4A5    1. 31 mutation in COL4A5 associated with autosomal dominant Alport syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COL4A5 antibodyPathways associated with anti-COL4A5 antibody
 Reference Product  PubMed Publications
 COL4A3 antibody  >97 publications with COL4A5 and COL4A3
 COL4A4 antibody  >91 publications with COL4A5 and COL4A4
 COL4A6 antibody  >51 publications with COL4A5 and COL4A6
 COL4A2 antibody  >12 publications with COL4A5 and COL4A2
 COL1A1 antibody  >7 publications with COL4A5 and COL1A1
 COL1A2 antibody  >6 publications with COL4A5 and COL1A2
 COL18A1 antibody  >1 publications with COL4A5 and COL18A1
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with anti-COL4A5 antibodyOrgans/Tissues associated with anti-COL4A5 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >303 publications with COL4A5 and Kidney Diseases
 ALPORT SYNDROME, X-LINKED Antibodies  >286 publications with COL4A5 and ALPORT SYNDROME, X-LINKED
 Proteinuria Antibodies  >54 publications with COL4A5 and Proteinuria
 Hearing Loss, Sensorineural Antibodies  >39 publications with COL4A5 and Hearing Loss, Sensorineural
 Disease Models, Animal Antibodies  >18 publications with COL4A5 and Disease Models, Animal
 Autoimmune Diseases Antibodies  >11 publications with COL4A5 and Autoimmune Diseases
 Fibrosis Antibodies  >5 publications with COL4A5 and Fibrosis
 Inflammation Antibodies  >5 publications with COL4A5 and Inflammation
 Lung Diseases Antibodies  >4 publications with COL4A5 and Lung Diseases
 Heart Defects, Congenital Antibodies  >3 publications with COL4A5 and Heart Defects, Congenital
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >181 publications with COL4A5 and Kidney
 Muscle Antibodies  >28 publications with COL4A5 and Muscle
 Eye Antibodies  >25 publications with COL4A5 and Eye
 Vascular Antibodies  >13 publications with COL4A5 and Vascular
 Ear Antibodies  >12 publications with COL4A5 and Ear
 Bone Antibodies  >6 publications with COL4A5 and Bone
 Brain Antibodies  >6 publications with COL4A5 and Brain
 Embryonic Tissue Antibodies  >5 publications with COL4A5 and Embryonic Tissue
 Liver Antibodies  >3 publications with COL4A5 and Liver
 Lung Antibodies  >3 publications with COL4A5 and Lung
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