NP_033906.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
plasma protease C1 inhibitor
NCBI Official Synonym Full Names
serine (or cysteine) peptidase inhibitor, clade G, member 1
NCBI Official Synonym Symbols
NCBI Protein Information
plasma protease C1 inhibitor
UniProt Protein Name
Plasma protease C1 inhibitor
UniProt Synonym Protein Names
C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
UniProt Synonym Gene Names
UniProt Comments for C1INH
SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2|2 D
Cellular Component: extracellular region; extracellular space
Molecular Function: complement binding; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity
Biological Process: blood coagulation; complement activation, classical pathway; fibrinolysis; hemostasis; immune system process; innate immune response; negative regulation of complement activation; negative regulation of complement activation, lectin pathway; negative regulation of peptidase activity; regulation of blood coagulation
Research Articles on C1INH
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Products associated with anti-C1INH antibody
Pathways associated with anti-C1INH antibody
Diseases associated with anti-C1INH antibody
Organs/Tissues associated with anti-C1INH antibody
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