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anti-C1QB antibody :: Mouse anti-Human Complement C1qB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS626220 anti-C1QB antibody
Unit / Price
0.05 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C1qB, Polyclonal Antibody

 Also Known As   

Complement C1qB (Complement C1q Subcomponent Subunit B, Complement Component C1q B Chain, Complement Subcomponent C1q Chain B, C1QB)

 Product Synonym Names    Anti -Complement C1qB (Complement C1q Subcomponent Subunit B, Complement Component C1q B Chain, Complement Subcomponent C1q Chain B, C1QB)
 Product Gene Name   

anti-C1QB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (22979682..22988029). Location: 1p36.12
 OMIM    120570
 3D Structure    ModBase 3D Structure for P02746
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 Clonality    Polyclonal
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human C1QB.
 Purity/Purification    Purified
Purified.
 Form/Format    Supplied as a liquid in PBS, pH 7.2.
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 Immunogen    C1QB (1-254aa) full-length human protein.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-C1QB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-C1QB antibody

   C1QB is a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.
 Product Categories/Family for anti-C1QB antibody    Antibodies; Abs to Complement
 Applications Tested/Suitable for anti-C1QB antibody   

Western Blot (WB)

 Application Notes for anti-C1QB antibody    Suitable for use in Western Blot.
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NCBI/Uniprot data below describe general gene information for C1QB. It may not necessarily be applicable to this product.
 NCBI GI #    87298828
 NCBI GeneID    713
 NCBI Accession #    NP_000482.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000491.3 [Other Products]
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 UniProt Primary Accession #    P02746 [Other Products]
 UniProt Secondary Accession #    Q5T959; Q96H17 [Other Products]
 UniProt Related Accession #    P02746; Q5T960; Q6LDZ7 [Other Products]
 Molecular Weight    26,722 Da [Similar Products]
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 NCBI Official Full Name    complement C1q subcomponent subunit B
 NCBI Official Synonym Full Names    complement component 1, q subcomponent, B chain
 NCBI Official Symbol    C1QB [Similar Products]
 NCBI Protein Information    complement C1q subcomponent subunit B; OTTHUMP00000002940; OTTHUMP00000002941; complement component C1q, B chain; complement subcomponent C1q chain B; complement component 1, q subcomponent, beta polypeptide
 UniProt Protein Name    Complement C1q subcomponent subunit B
 Protein Family    Complement C1q subcomponent
 UniProt Gene Name    C1QB [Similar Products]
 UniProt Entry Name    C1QB_HUMAN
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 NCBI Summary for C1QB    This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq]
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 UniProt Comments for C1QB    C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: collagen; extracellular region; complement component C1 complex

Molecular Function: protein binding; protein homodimerization activity

Biological Process: innate immune response; complement activation, classical pathway; inner ear development; complement activation

Disease: C1q Deficiency
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 Research Articles on C1QB    1. In a large family-based association study of C1Q gene cluster polymorphisms no evidence for a genetic role of C1Q locus SNP in systemic lupus erythematosus risk predisposition was obtained in patients of European ancestry.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C1QB antibodyPathways associated with anti-C1QB antibody
 Reference Product  PubMed Publications
 C1QA antibody  >14 publications with C1QB and C1QA
 C1QC antibody  >10 publications with C1QB and C1QC
 C1R antibody  >5 publications with C1QB and C1R
 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-C1QB antibodyOrgans/Tissues associated with anti-C1QB antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with C1QB and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >12 publications with C1QB and Central Nervous System Diseases
 Autoimmune Diseases Antibodies  >10 publications with C1QB and Autoimmune Diseases
 Neurodegenerative Diseases Antibodies  >8 publications with C1QB and Neurodegenerative Diseases
 Inflammation Antibodies  >6 publications with C1QB and Inflammation
 Alzheimer Disease Antibodies  >6 publications with C1QB and Alzheimer Disease
 Liver Diseases Antibodies  >3 publications with C1QB and Liver Diseases
 Neoplasms Antibodies  >3 publications with C1QB and Neoplasms
 Kidney Diseases Antibodies  >3 publications with C1QB and Kidney Diseases
 Memory Disorders Antibodies  >2 publications with C1QB and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with C1QB and Brain
 Liver Antibodies  >3 publications with C1QB and Liver
 Vascular Antibodies  >3 publications with C1QB and Vascular
 Kidney Antibodies  >2 publications with C1QB and Kidney
 Spleen Antibodies  >2 publications with C1QB and Spleen
 Lung Antibodies  >2 publications with C1QB and Lung
 Skin Antibodies  >1 publications with C1QB and Skin
 Eye Antibodies  >1 publications with C1QB and Eye
 Mammary Gland Antibodies  >1 publications with C1QB and Mammary Gland
 Connective Tissue Antibodies  >1 publications with C1QB and Connective Tissue
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