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anti-C3 antibody :: Goat anti-Rabbit Complement C3, C3c Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6003284 anti-C3 antibody
Unit / Price
1 mL  /  $595 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C3, C3c, Polyclonal Antibody

★Popular Item★
 Also Known As   

Complement C3, C3c (Complement Component C3c, C3/C3c, Acylation Stimulating Protein Cleavage Product, ASP, AHUS5, ARMD9, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 1, Complement Component 3, Complement Factor 3, CPAMD1) (FITC)

 Product Synonym Names    Goat anti Rabbit Complement C3, C3c (ASP, AHUS5, ARMD9, CPAMD1) (FITC)
 Product Gene Name   

anti-C3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; AC_000164.1 (18989619..19025598). Location: chromosome: 7
 3D Structure    ModBase 3D Structure for Q2UVX4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Rabbit
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 Specificity    Recognizes rabbit C3, C3c. In immunoelectrophoresis against fresh rabbit serum, a single precipitin line is obtained in the beta-1 region representing native C3. Against serum containing partly activated C3, a precipitin line is obtained which extends from the beta-1 into the alpha-2 region, demonstrating a gradient. In old serum containing totally activated C3 a single precipitin line in the alpha-2 region is obtained. Also reacts with the fragments C3b, C3bi and smaller fragments, since they all carry antigenic determinants of the C3c domain. Does not react with any other proteins component of rabbit serum or plasma.
 Purity/Purification    Purified
 Form/Format    Supplied as a lyophilized powder from PBS, pH 7.2. No preservatives added. Labeled with Fluorescein isothiocyanate (FITC). Reconstitute in 1ml sterile ddH2O. Dilute further in PBS, pH 7.2.
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 Immunogen    C3c isolated and purified from pooled normal rabbit serum
 Emission    515nm
 Excitation    492nm
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-C3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-C3 antibody

   C3c is the major fragment resulting from C3 cleavage by C3 convertase and factor I. It is composed of an intact beta chain bound to two fragments of the alpha chain.
 Product Categories/Family for anti-C3 antibody    Antibodies; Abs to Complement
 Applications Tested/Suitable for anti-C3 antibody   

FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC). Other applications not tested.

 Application Notes for anti-C3 antibody    Recommended Dilution:
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for C3. It may not necessarily be applicable to this product.
 NCBI GI #    99028969
 NCBI GeneID    280677
 NCBI Accession #    NP_001035559.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040469.2 [Other Products]
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 UniProt Primary Accession #    Q2UVX4 [Other Products]
 UniProt Secondary Accession #    Q2KIZ4 [Other Products]
 UniProt Related Accession #    Q2UVX4 [Other Products]
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 NCBI Official Full Name    complement C3 preproprotein
 NCBI Official Synonym Full Names    complement component 3<
 NCBI Official Symbol    C3 [Similar Products]
 NCBI Protein Information    complement C3
 UniProt Protein Name    Complement C3
 UniProt Synonym Protein Names   
C3adesArg
 Protein Family    Complement C3
 UniProt Gene Name    C3 [Similar Products]
 UniProt Synonym Gene Names    ASP [Similar Products]
 UniProt Entry Name    CO3_BOVIN
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 UniProt Comments for C3    Function: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates

By similarity.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes

By similarity.Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-internalization and recycling of C5AR2

By similarity.

Subunit structure: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). Interacts with VSIG4. Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis of GRP77

By similarity. Interacts with BHV-1 glycoprotein C. Ref.3

Subcellular location: Secreted.

Post-translational modification: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by dietary chylomicrons

By similarity.Phosphorylation sites are present in the extracellular medium

By similarity.

Sequence similarities: Contains 1 anaphylatoxin-like domain.Contains 1 NTR domain.
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 Research Articles on C3    1. The structure of bovine C3 clearly demonstrates that the main chain around the thioester undergoes a helical transition upon activation, a rearrangement that is proposed to be the basis for the high level of reactivity of the thioester group.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-C3 antibodyDiseases associated with anti-C3 antibody
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alternative Complement Activation Pathway antibodies  Alternative Complement Activation Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3514 publications with C3 and Kidney Diseases
 Neoplasms Antibodies  >2640 publications with C3 and Neoplasms
 Nervous System Diseases Antibodies  >2624 publications with C3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2275 publications with C3 and Cardiovascular Diseases
 Inflammation Antibodies  >1795 publications with C3 and Inflammation
 Proteinuria Antibodies  >1218 publications with C3 and Proteinuria
 Lung Diseases Antibodies  >986 publications with C3 and Lung Diseases
 Pain Antibodies  >907 publications with C3 and Pain
 Liver Diseases Antibodies  >893 publications with C3 and Liver Diseases
 Necrosis Antibodies  >888 publications with C3 and Necrosis
Organs/Tissues associated with anti-C3 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3358 publications with C3 and Kidney
 Skin Antibodies  >2200 publications with C3 and Skin
 Brain Antibodies  >1981 publications with C3 and Brain
 Liver Antibodies  >1721 publications with C3 and Liver
 Muscle Antibodies  >1609 publications with C3 and Muscle
 Intestine Antibodies  >379 publications with C3 and Intestine
 Uterus Antibodies  >183 publications with C3 and Uterus
 Adipose Tissue Antibodies  >121 publications with C3 and Adipose Tissue
 Ovary Antibodies  >116 publications with C3 and Ovary
 Reticulum Antibodies  >113 publications with C3 and Reticulum
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