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anti-C3 antibody :: Rabbit anti-Mouse Complement C3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1488663 anti-C3 antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C3, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-mouse Complement C3 polyclonal Antibody, HRP conjugated

 Product Synonym Names    HSE-MSF; ASP; C3adesArg
 Product Gene Name   

anti-C3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P01027
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    HRP
 Immunogen    Recombinant mouse Complement C3 protein
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-C3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-C3 antibody

   C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. The short isoform hasB-cell stimulatory activity. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.
 Applications Tested/Suitable for anti-C3 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for C3. It may not necessarily be applicable to this product.
 NCBI GI #    126518317
 NCBI GeneID    12266
 NCBI Accession #    NP_033908.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_009778.3 [Other Products]
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 UniProt Primary Accession #    P01027 [Other Products]
 UniProt Secondary Accession #    Q61370; Q80XP1 [Other Products]
 UniProt Related Accession #    P01027 [Other Products]
 Molecular Weight    60,952 Da
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 NCBI Official Full Name    complement C3 preproprotein
 NCBI Official Synonym Full Names    complement component 3
 NCBI Official Symbol    C3 [Similar Products]
 NCBI Official Synonym Symbols   
ASP; Plp; HSE-MSF; AI255234
[Similar Products]
 NCBI Protein Information    complement C3
 UniProt Protein Name    Complement C3
 UniProt Synonym Protein Names   
HSE-MSF
 Protein Family    Complement C3
 UniProt Gene Name    C3 [Similar Products]
 UniProt Synonym Gene Names    C3bc; ASP [Similar Products]
 UniProt Entry Name    CO3_MOUSE
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 NCBI Summary for C3    This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome. [provided by RefSeq, Mar 2015]
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 UniProt Comments for C3    C3: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Defects in C3 are the cause of complement component 3 deficiency (C3D). A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis. Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin- containing structure known as Bruch membrane. Defects in C3 are a cause of susceptibility to hemolytic uremic syndrome atypical type 5 (AHUS5). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Cellular Component: extracellular region; extracellular space

Molecular Function: C5L2 anaphylatoxin chemotactic receptor binding; cofactor binding; endopeptidase inhibitor activity; lipid binding; protein binding

Biological Process: blood coagulation; complement activation; complement activation, alternative pathway; complement activation, classical pathway; fatty acid metabolic process; immune system process; inflammatory response; innate immune response; lipid metabolic process; positive regulation of activation of membrane attack complex; positive regulation of angiogenesis; positive regulation of developmental growth; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of phagocytosis; positive regulation of protein amino acid phosphorylation; positive regulation of type IIa hypersensitivity
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 Research Articles on C3    1. Complement component 3 is up-regulated via non-canonical TGF-beta signaling in the retinal pigment epithelium
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C3 antibodyPathways associated with anti-C3 antibody
 Reference Product  PubMed Publications
 Cfh antibody  >238 publications with C3 and Cfh
 Cd46 antibody  >212 publications with C3 and Cd46
 Cfb antibody  >101 publications with C3 and Cfb
 Cfi antibody  >89 publications with C3 and Cfi
 Itgam antibody  >76 publications with C3 and Itgam
 Cfhr1 antibody  >51 publications with C3 and Cfhr1
 Cfhr3 antibody  >30 publications with C3 and Cfhr3
 C5ar1 antibody  >23 publications with C3 and C5ar1
 Cfd antibody  >6 publications with C3 and Cfd
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alternative Complement Activation Pathway antibodies  Alternative Complement Activation Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
Diseases associated with anti-C3 antibodyOrgans/Tissues associated with anti-C3 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3831 publications with C3 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >2528 publications with C3 and Cardiovascular Diseases
 Inflammation Antibodies  >2100 publications with C3 and Inflammation
 Proteinuria Antibodies  >1343 publications with C3 and Proteinuria
 Lung Diseases Antibodies  >1043 publications with C3 and Lung Diseases
 Brain Diseases Antibodies  >1016 publications with C3 and Brain Diseases
 Necrosis Antibodies  >978 publications with C3 and Necrosis
 Liver Diseases Antibodies  >975 publications with C3 and Liver Diseases
 Hemorrhage Antibodies  >807 publications with C3 and Hemorrhage
 Anemia Antibodies  >793 publications with C3 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12301 publications with C3 and Blood
 Other Antibodies  >6992 publications with C3 and Other
 Kidney Antibodies  >3688 publications with C3 and Kidney
 Bone Antibodies  >3183 publications with C3 and Bone
 Skin Antibodies  >2341 publications with C3 and Skin
 Liver Antibodies  >1890 publications with C3 and Liver
 Muscle Antibodies  >1765 publications with C3 and Muscle
 Joint Antibodies  >1312 publications with C3 and Joint
 Lung Antibodies  >1138 publications with C3 and Lung
 Heart Antibodies  >1061 publications with C3 and Heart
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