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anti-C3 antibody :: Rabbit Complement Component 3 (C3) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2005172 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $330 +1 FREE 8GB USB
1 mg  /  $785 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement Component 3 (C3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Complement Component 3 (C3)

 Product Gene Name   

anti-C3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2005172 Technical Datasheet    Technical Datasheet PDF
 3D Structure    ModBase 3D Structure for P01026
 Clonality    Polyclonal
 Host    Rabbit
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 Purity/Purification    Antigen-specific affinity chromatography followed by Protein A affinity chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
 Concentration    0.63 mg/ml (lot specific)
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 Organism Species    Rattus norvegicus (Rat)
 Source    Polyclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant Complement Component 3 (Asp966~Trp1313 (Accession #P01026)) expressed in E.coli
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2048851
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-C3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-C3 antibody   

WB; IHC; ICC; IP.

 Application Notes for anti-C3 antibody    Western blotting: 0.5-2 ug/mL;1:300-1200
Immunohistochemistry: 5-20 ug/mL;1:30-120
Immunocytochemistry: 5-20 ug/mL;1:30-120

Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-C3 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-C3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-C3 antibody    (Figure.DAB staining on IHC-P. Samples: Rat Tissue)
anti-C3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for C3. It may not necessarily be applicable to this product.
 NCBI GI #    158138561
 NCBI GeneID    24232
 NCBI Accession #    NP_058690.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_016994.2 [Other Products]
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 UniProt Primary Accession #    P01026 [Other Products]
 UniProt Secondary Accession #    Q9ET19; Q9QV57; Q9QV58 [Other Products]
 UniProt Related Accession #    P01026 [Other Products]
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 NCBI Official Full Name    complement C3
 NCBI Official Synonym Full Names    complement C3
 NCBI Official Symbol    C3 [Similar Products]
 NCBI Protein Information    complement C3
 UniProt Protein Name    Complement C3
 UniProt Synonym Protein Names   
Complement C3 beta chainC3-beta-c; C3bc
 Protein Family    Complement C3
 UniProt Gene Name    C3 [Similar Products]
 UniProt Synonym Gene Names    C3bc; ENCF-2; ENCF-1; ASP [Similar Products]
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 NCBI Summary for C3    putative complement component C3; likely involved in innate immune response [RGD, Feb 2006]
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 UniProt Comments for C3    C3: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Defects in C3 are the cause of complement component 3 deficiency (C3D). A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis. Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin- containing structure known as Bruch membrane. Defects in C3 are a cause of susceptibility to hemolytic uremic syndrome atypical type 5 (AHUS5). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q12

Cellular Component: extracellular space; protein complex

Molecular Function: C5L2 anaphylatoxin chemotactic receptor binding; cofactor binding; endopeptidase inhibitor activity; lipid binding; protein binding

Biological Process: blood coagulation; chemotaxis; complement activation; complement activation, alternative pathway; complement activation, classical pathway; fatty acid metabolic process; inflammatory response; phagocytosis, engulfment; positive regulation of activation of membrane attack complex; positive regulation of angiogenesis; positive regulation of developmental growth; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of phagocytosis; positive regulation of protein phosphorylation; positive regulation of type IIa hypersensitivity; response to estradiol; response to estrogen; response to glucocorticoid stimulus; response to magnesium ion; response to progesterone; tolerance induction
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 Research Articles on C3    1. These data suggest that locally produced C3 is an important prosurvival mechanism in pancreatic beta-cells under a proinflammatory assault.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C3 antibodyPathways associated with anti-C3 antibody
 Reference Product  PubMed Publications
 Cd55 antibody  >379 publications with C3 and Cd55
 Cfh antibody  >268 publications with C3 and Cfh
 Cd46 antibody  >219 publications with C3 and Cd46
 Cfp antibody  >15 publications with C3 and Cfp
 Itgam antibody  >12 publications with C3 and Itgam
 Plg antibody  >11 publications with C3 and Plg
 Cfd antibody  >9 publications with C3 and Cfd
 Itgb2 antibody  >6 publications with C3 and Itgb2
 Itgax antibody  >1 publications with C3 and Itgax
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alternative Complement Activation Pathway antibodies  Alternative Complement Activation Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
Diseases associated with anti-C3 antibodyOrgans/Tissues associated with anti-C3 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3973 publications with C3 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >2630 publications with C3 and Cardiovascular Diseases
 Inflammation Antibodies  >2256 publications with C3 and Inflammation
 Disease Models, Animal Antibodies  >1399 publications with C3 and Disease Models, Animal
 Proteinuria Antibodies  >1387 publications with C3 and Proteinuria
 Lung Diseases Antibodies  >1079 publications with C3 and Lung Diseases
 Necrosis Antibodies  >1025 publications with C3 and Necrosis
 Liver Diseases Antibodies  >1008 publications with C3 and Liver Diseases
 Hemorrhage Antibodies  >840 publications with C3 and Hemorrhage
 Anemia Antibodies  >834 publications with C3 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2352 publications with C3 and Brain
 Liver Antibodies  >1967 publications with C3 and Liver
 Lung Antibodies  >1181 publications with C3 and Lung
 Spleen Antibodies  >724 publications with C3 and Spleen
 Eye Antibodies  >655 publications with C3 and Eye
 Connective Tissue Antibodies  >641 publications with C3 and Connective Tissue
 Prostate Antibodies  >211 publications with C3 and Prostate
 Adipose Tissue Antibodies  >175 publications with C3 and Adipose Tissue
 Placenta Antibodies  >158 publications with C3 and Placenta
 Cervix Antibodies  >51 publications with C3 and Cervix
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