AAH20702.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,163 Da
NCBI Official Full Name
C8A protein, partial
NCBI Official Synonym Full Names
complement C8 alpha chain
NCBI Protein Information
complement component C8 alpha chain
UniProt Protein Name
Complement component C8 alpha chain
UniProt Synonym Protein Names
Complement component 8 subunit alpha
NCBI Summary for C8a
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
UniProt Comments for C8a
C8A: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p32.2
Cellular Component: extracellular region; extracellular space; membrane; membrane attack complex
Biological Process: complement activation; immune response; regulation of complement activation
Disease: Complement Component 8 Deficiency, Type I
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Products associated with anti-C8a antibody
Pathways associated with anti-C8a antibody
Diseases associated with anti-C8a antibody
Organs/Tissues associated with anti-C8a antibody
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