NP_666260.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,080 Da
NCBI Official Full Name
complement component C8 alpha chain isoform 1 preproprotein
NCBI Official Synonym Full Names
complement component 8, alpha polypeptide
NCBI Protein Information
complement component C8 alpha chain
UniProt Protein Name
Complement component C8 alpha chain
UniProt Synonym Protein Names
Complement component 8 subunit alpha
NCBI Summary for C8a
This gene encodes the alpha subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the alpha subunit, which associates with the beta and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the beta subunit. [provided by RefSeq, Oct 2015]
UniProt Comments for C8a
C8A: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4|4 C6
Cellular Component: extracellular region; extracellular space; integral component of membrane; membrane; membrane attack complex; plasma membrane
Molecular Function: complement binding; protein complex binding
Biological Process: complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; immune response; immune system process; innate immune response
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Pathways associated with anti-C8a antibody
Diseases associated with anti-C8a antibody
Organs/Tissues associated with anti-C8a antibody
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