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anti-CFB antibody :: Rabbit anti-Mouse Complement Factor B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS524116 anti-CFB antibody
Unit / Price
0.1 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement Factor B (CFB), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Mouse Complement Factor B, Purified, (Polyclonal) (Rabbit IgG)

 Product Synonym Names    Complement Factor B, Purified, (Polyclonal) (Rabbit IgG); Purified Rabbit Anti-Mouse Complement Factor B Polyclonal Antibody
 Product Gene Name   

anti-CFB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (31913721..31919861). Location: 6p21.3
 OMIM    138470
 3D Structure    ModBase 3D Structure for P00751
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 Clonality    Polyclonal
 Isotype    Rabbit IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    Mouse Complement Factor B/Bb. WB analysis shows that the antibody may also cross-react with a Ba fragment.
 Form/Format    Purified
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 Immunogen    15 amino acid synthetic peptide of mouse Complement Factor B (within Bb fragment).
 Presentation    100 ug purified IgG buffered in PBS and 0.02% NaN3. (Purified from serum via Affinity Chromatography). For maximum recovery of contents, spin down tube before use.
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 Preparation and Storage    Store at + 4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CFB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CFB antibody

   Complement factor B is an essential protein in the alternative complement pathway. It is expressed by hepatocytes and macrophages and localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Factor B circulates in the blood as a single chain polypeptide of 764 amino acids (MW of 90 kDa). Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is also involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. Factor B is an acute-phase protein whose levels increase during inflammation.
 Applications Tested/Suitable for anti-CFB antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CFB antibody    Suggested minimum working dilution of 1:100 in Western Blot and 1:8000 in ELISA. This antibody has not been tested in other applications
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NCBI/Uniprot data below describe general gene information for CFB. It may not necessarily be applicable to this product.
 NCBI GI #    297569
 NCBI GeneID    629
 NCBI Accession #    CAA51389.1 [Other Products]
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 UniProt Primary Accession #    P00751 [Other Products]
 UniProt Secondary Accession #    O15006; Q29944; Q5JP67; Q5ST50; Q96HX6; Q9BTF5; Q9BX92; B0QZQ6 [Other Products]
 UniProt Related Accession #    P00751 [Other Products]
 Molecular Weight    85,533 Da [Similar Products]
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 NCBI Official Full Name    complement factor B
 NCBI Official Synonym Full Names    complement factor B
 NCBI Official Symbol    CFB [Similar Products]
 NCBI Official Synonym Symbols   
BF; FB; BFD; GBG; CFAB; PBF2; AHUS4; FBI12; H2-Bf
[Similar Products]
 NCBI Protein Information    complement factor B; C3 proactivator; C3/C5 convertase; C3 proaccelerator; properdin factor B; B-factor, properdin; glycine-rich beta glycoprotein; glycine-rich beta-glycoprotein
 UniProt Protein Name    Complement factor B
 UniProt Synonym Protein Names   
C3/C5 convertase; Glycine-rich beta glycoprotein; GBG; PBF2; Properdin factor B
 Protein Family    Complement factor
 UniProt Gene Name    CFB [Similar Products]
 UniProt Synonym Gene Names    BF; BFD; GBG [Similar Products]
 UniProt Entry Name    CFAB_HUMAN
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 NCBI Summary for CFB    This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CFB    Function: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Catalytic activity: Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.

Subunit structure: Monomer.

Subcellular location: Secreted.

Polymorphism: Two major variants, F and S, and 2 minor variants, as well as at least 14 very rare variants, have been identified. The variants His-9 and Gln-32 are associated with a reduced risk of age-related macular degeneration (ARMD) [

MIM:603075]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world.

Involvement in disease: Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Ref.22 Ref.23

Sequence similarities: Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain.Contains 3 Sushi (CCP/SCR) domains.Contains 1 VWFA domain.
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 Research Articles on CFB    1. Gain of function mutation in factor B is associated with recurrence in adult renal transplant recipients with atypical hemolytic and uremic syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CFB antibodyDiseases associated with anti-CFB antibody
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Alternative Complement Activation Pathway antibodies  Alternative Complement Activation Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Disease Name  Pubmed Publications
 Macular Degeneration Antibodies  >69 publications with CFB and Macular Degeneration
 Macular Degeneration, Age-Related, 1 Antibodies  >37 publications with CFB and Macular Degeneration, Age-Related, 1
 Cardiovascular Diseases Antibodies  >19 publications with CFB and Cardiovascular Diseases
 Immune System Diseases Antibodies  >17 publications with CFB and Immune System Diseases
 Inflammation Antibodies  >16 publications with CFB and Inflammation
 Necrosis Antibodies  >13 publications with CFB and Necrosis
 Nervous System Diseases Antibodies  >13 publications with CFB and Nervous System Diseases
 Neoplasms Antibodies  >13 publications with CFB and Neoplasms
 Fibrosis Antibodies  >12 publications with CFB and Fibrosis
 Kidney Diseases Antibodies  >11 publications with CFB and Kidney Diseases
Organs/Tissues associated with anti-CFB antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >68 publications with CFB and Blood
 Eye Antibodies  >57 publications with CFB and Eye
 Heart Antibodies  >33 publications with CFB and Heart
 Muscle Antibodies  >26 publications with CFB and Muscle
 Liver Antibodies  >23 publications with CFB and Liver
 Kidney Antibodies  >13 publications with CFB and Kidney
 Intestine Antibodies  >12 publications with CFB and Intestine
 Bone Antibodies  >9 publications with CFB and Bone
 Brain Antibodies  >8 publications with CFB and Brain
 Lung Antibodies  >7 publications with CFB and Lung
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