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anti-CX43 antibody :: Rabbit anti-Mouse Connexin 43 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2026016 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $315 +1 FREE 8GB USB
1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Connexin 43 (CX43), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Connexin 43 (CX43)

 Product Gene Name   

anti-CX43 antibody

[Similar Products]
 Matching Pairs    Antibody: Connexin 43 (MBS2026016)
Antigen: Connexin 43 (MBS2029380)
 Matching Pairs    Unconjugated Antibody: Connexin 43 (MBS2026016)
APC-CY7 Conjugated Antibody: Connexin 43 (CX43) (MBS2040424)
 Matching Pairs    Unconjugated Antibody: Connexin 43 (MBS2026016)
PE Conjugated Antibody: Connexin 43 (CX43) (MBS2040425)
 Matching Pairs    Unconjugated Antibody: Connexin 43 (MBS2026016)
APC-CY7 Conjugated Antibody: Connexin 43 (CX43) (MBS2040426)
 Matching Pairs    Unconjugated Antibody: Connexin 43 (MBS2026016)
Cy3 Conjugated Antibody: Connexin 43 (CX43) (MBS2040427)
 Matching Pairs    Unconjugated Antibody: Connexin 43 (MBS2026016)
FITC Conjugated Antibody: Connexin 43 (CX43) (MBS2040428)
 Matching Pairs    Unconjugated Antibody: Connexin 43 (MBS2026016)
HRP Conjugated Antibody: Connexin 43 (CX43) (MBS2040429)
 Matching Pairs    Unconjugated Antibody: Connexin 43 (MBS2026016)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Connexin 43 (MBS2026016)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Connexin 43 (MBS2026016)
Biotin Conjugated Antibody: Connexin 43 (CX43) (MBS2091794)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- S LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV KGRSDPYHAT TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD SQNAKKVAAG HELQPLAIVD QRPSSRASSR
 3D Structure    ModBase 3D Structure for P23242
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    The antibody is a rabbit polyclonal antibody raised against CX43. It has beenselected for its ability to recognize CX43 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    CX43 (Ser180~Ile382)
 Organism Species    Mus musculus (Mouse)
 Conjugate    No Conjugate
 Immunogen    Recombinant CX43 (Ser180~Ile382) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2040426
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-CX43 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CX43 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-CX43 antibody    Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-CX43 antibody    (Figure. Western Blot; Sample: Mouse Brain Tissue.)
anti-CX43 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-CX43 antibody    (Figure. Western Blot; Sample: Recombinant CX43, Mouse.)
anti-CX43 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CX43 antibody    (Figure.DAB staining on IHC-P. Samples: Mouse Tissue)
anti-CX43 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CX43. It may not necessarily be applicable to this product.
 NCBI GI #    6753992
 NCBI GeneID    14609
 NCBI Accession #    NP_034418.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010288.3 [Other Products]
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 UniProt Primary Accession #    P23242 [Other Products]
 UniProt Secondary Accession #    Q544I7; Q8CE05 [Other Products]
 UniProt Related Accession #    P23242 [Other Products]
 Molecular Weight    43,004 Da
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 NCBI Official Full Name    gap junction alpha-1 protein
 NCBI Official Synonym Full Names    gap junction protein, alpha 1
 NCBI Official Symbol    Gja1 [Similar Products]
 NCBI Official Synonym Symbols   
Cx43; Npm1; Cnx43; Gja-1; AU042049; AW546267; Cx43alpha1; connexin43
[Similar Products]
 NCBI Protein Information    gap junction alpha-1 protein
 UniProt Protein Name    Gap junction alpha-1 protein
 UniProt Synonym Protein Names   
Connexin-43; Cx43; Gap junction 43 kDa heart protein
 UniProt Gene Name    Gja1 [Similar Products]
 UniProt Synonym Gene Names    Cxn-43; Cx43 [Similar Products]
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 UniProt Comments for CX43    GJA1: an integral membrane protein of the connexin family, alpha-type (group II) subfamily. Hexamers of connexin-43 form connexons, which aggregate together to form gap junctions, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.

Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10 B4|10 28.64 cM

Cellular Component: apical plasma membrane; cell junction; connexin complex; contractile fiber; cytoplasm; cytosol; early endosome; endoplasmic reticulum; endosome; extracellular exosome; fascia adherens; focal adhesion; gap junction; Golgi apparatus; integral component of membrane; intercalated disc; intercellular junction; intermediate filament; late endosome; lateral plasma membrane; lysosome; membrane; membrane raft; mitochondrial outer membrane; mitochondrion; multivesicular body; plasma membrane; protein complex

Molecular Function: beta-tubulin binding; gap junction channel activity; gap junction channel activity involved in cardiac conduction electrical coupling; ion transmembrane transporter activity; PDZ domain binding; protein binding; protein domain specific binding; receptor binding; SH3 domain binding; signal transducer activity; transmembrane transporter activity

Biological Process: adult heart development; apoptosis; ATP transport; atrial ventricular junction remodeling; blood vessel morphogenesis; cell communication; cell communication by chemical coupling; cell communication by electrical coupling; cell-cell junction organization; cell-cell signaling; cellular response to pH; chronic inflammatory response; elevation of cytosolic calcium ion concentration; embryonic digit morphogenesis; embryonic heart tube development; epicardial cell to mesenchymal cell transition; epithelial cell maturation; establishment of epithelial cell polarity; heart development; heart looping; in utero embryonic development; lens development in camera-type eye; milk ejection reflex; negative regulation of cardiac muscle cell proliferation; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of DNA biosynthetic process; negative regulation of endothelial cell proliferation; negative regulation of gene expression; neuron migration; neuron projection morphogenesis; osteoblast differentiation; positive regulation of behavioral fear response; positive regulation of blood vessel diameter; positive regulation of cell communication by chemical coupling; positive regulation of gene expression; positive regulation of glomerular filtration; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of osteoblast differentiation; positive regulation of protein catabolic process; positive regulation of striated muscle tissue development; positive regulation of vasoconstriction; protein oligomerization; regulation of bicellular tight junction assembly; regulation of bone mineralization; regulation of bone remodeling; regulation of calcium ion transport; regulation of heart contraction; regulation of transmembrane transporter activity; response to pH; signal transduction; skeletal muscle tissue regeneration; transmembrane transport; vascular transport
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 Research Articles on CX43    1. The astroglial targeted connexin43 gene knocking-out in APPswe/PS1dE9 mice allowed to diminish gliotransmitter release and to alleviate neuronal damages, reducing oxidative stress and neuritic dystrophies in hippocampal neurons associated to plaques.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CX43 antibodyPathways associated with anti-CX43 antibody
 Reference Product  PubMed Publications
 Jun antibody  >67 publications with CX43 and Jun
 Tjp1 antibody  >18 publications with CX43 and Tjp1
 Cdh2 antibody  >9 publications with CX43 and Cdh2
 Src antibody  >7 publications with CX43 and Src
 Akt1 antibody  >2 publications with CX43 and Akt1
 Mapk1 antibody  >2 publications with CX43 and Mapk1
 Vcl antibody  >1 publications with CX43 and Vcl
 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Formation Of Annular Gap Junctions Pathway antibodies  Formation Of Annular Gap Junctions Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Assembly Pathway antibodies  Gap Junction Assembly Pathway Diagram
 Gap Junction Degradation Pathway antibodies  Gap Junction Degradation Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram
Diseases associated with anti-CX43 antibodyOrgans/Tissues associated with anti-CX43 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >92 publications with CX43 and Heart Diseases
 Oculodentodigital Dysplasia Antibodies  >66 publications with CX43 and Oculodentodigital Dysplasia
 Disease Models, Animal Antibodies  >55 publications with CX43 and Disease Models, Animal
 Arrhythmias, Cardiac Antibodies  >55 publications with CX43 and Arrhythmias, Cardiac
 Inflammation Antibodies  >23 publications with CX43 and Inflammation
 Necrosis Antibodies  >20 publications with CX43 and Necrosis
 Breast Neoplasms Antibodies  >16 publications with CX43 and Breast Neoplasms
 Fibrosis Antibodies  >15 publications with CX43 and Fibrosis
 Neoplasms, Experimental Antibodies  >13 publications with CX43 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >12 publications with CX43 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >152 publications with CX43 and Heart
 Muscle Antibodies  >147 publications with CX43 and Muscle
 Bone Antibodies  >80 publications with CX43 and Bone
 Eye Antibodies  >79 publications with CX43 and Eye
 Brain Antibodies  >56 publications with CX43 and Brain
 Skin Antibodies  >35 publications with CX43 and Skin
 Ovary Antibodies  >32 publications with CX43 and Ovary
 Embryonic Tissue Antibodies  >26 publications with CX43 and Embryonic Tissue
 Uterus Antibodies  >25 publications with CX43 and Uterus
 Bone Marrow Antibodies  >22 publications with CX43 and Bone Marrow
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