NP_005258.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,229 Da
NCBI Official Full Name
gap junction alpha-8 protein
NCBI Official Synonym Full Names
gap junction protein alpha 8
NCBI Official Synonym Symbols
CAE; CAE1; CX50; CZP1; MP70; CTRCT1 [Similar Products]
NCBI Protein Information
gap junction alpha-8 protein
UniProt Protein Name
Gap junction alpha-8 protein
UniProt Synonym Protein Names
Connexin-50; Cx50; Lens fiber protein MP70
UniProt Synonym Gene Names
UniProt Entry Name
CXA8_HUMAN
NCBI Summary for GJA8
This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009]
UniProt Comments for GJA8
GJA8: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. Eye lens. Belongs to the connexin family. Alpha-type (group II) subfamily.
Protein type: Channel, misc.; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q21.1
Cellular Component: connexon complex; integral to plasma membrane
Molecular Function: channel activity; gap junction channel activity
Biological Process: cell-cell signaling; lens development in camera-type eye; protein homooligomerization; transmembrane transport; transport; visual perception
Disease: Cataract 1, Multiple Types; Chromosome 1q21.1 Deletion Syndrome, 1.35-mb
Research Articles on GJA8
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-GJA8 antibody
Diseases associated with anti-GJA8 antibody
Organs/Tissues associated with anti-GJA8 antibody
|