NP_000481.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,325 Da
NCBI Official Full Name
vasopressin-neurophysin 2-copeptin preproprotein
NCBI Official Synonym Full Names
arginine vasopressin
NCBI Protein Information
vasopressin-neurophysin 2-copeptin
UniProt Protein Name
Vasopressin-neurophysin 2-copeptin
UniProt Synonym Protein Names
AVP-NPII
UniProt Synonym Gene Names
NCBI Summary for CPP
This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20. [provided by RefSeq, Nov 2015]
UniProt Comments for CPP
AVP: Neurophysin 2 specifically binds vasopressin. Defects in AVP are the cause of diabetes insipidus, neurohypophyseal (NDI). A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopression deficiency during childhood. Belongs to the vasopressin/oxytocin family.
Protein type: Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: clathrin-coated vesicle membrane; cytosol; dendrite; extracellular region; extracellular space; secretory granule
Molecular Function: caspase inhibitor activity; neurohypophyseal hormone activity; neuropeptide hormone activity; protein kinase activity; receptor binding; signal transducer activity; V1A vasopressin receptor binding; V1B vasopressin receptor binding
Biological Process: apoptosis; cell-cell signaling; elevation of cytosolic calcium ion concentration; generation of precursor metabolites and energy; grooming behavior; hyperosmotic salinity response; locomotory behavior; maternal behavior; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; positive regulation of cAMP biosynthetic process; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of prostaglandin biosynthetic process; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; renal water homeostasis; response to ethanol; response to nicotine; response to testosterone stimulus; signal transduction; social behavior; sodium-independent organic anion transport; vasoconstriction; water transport
Disease: Diabetes Insipidus, Neurohypophyseal
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Products associated with anti-CPP antibody
Pathways associated with anti-CPP antibody
Diseases associated with anti-CPP antibody
Organs/Tissues associated with anti-CPP antibody
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