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anti-HSD11B1 antibody :: Rabbit anti-Human, Mouse Corticosteroid 11-beta-dehydrogenase isozyme 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493323
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Corticosteroid 11-beta-dehydrogenase isozyme 1 polyclonal Antibody(HSD11B1)

 Product Synonym Names    11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; HSD11B1; HSD11; HSD11L
 Product Gene Name   

anti-HSD11B1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600713
 3D Structure    ModBase 3D Structure for P28845
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Corticosteroid 11-beta-dehydrogenase isozyme 1 protein (25-292aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-19259 / sc-19257 / sc-20175
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HSD11B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HSD11B1 antibody

   Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
 Applications Tested/Suitable for anti-HSD11B1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-HSD11B1 antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-HSD11B1 antibody    All lanes: Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody at 7ug/ml
Lane 1:mouse liver tissue
Lane 2:Jurkat whole cell lysate
Lane 2:LO2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 32kDa
Observed band size: 32kDa

anti-HSD11B1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HSD11B1 antibody    Immunohistochemistry of paraffin-embedded human liver using MBS1493323 at dilution 1:100
anti-HSD11B1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HSD11B1 antibody    Immunohistochemistry of paraffin-embedded human adrenal gland using MBS1493323 at dilution 1:100
anti-HSD11B1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HSD11B1. It may not necessarily be applicable to this product.
 NCBI GI #    332078483
 NCBI GeneID    3290
 NCBI Accession #    NP_001193670.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206741.1 [Other Products]
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 UniProt Primary Accession #    P28845 [Other Products]
 UniProt Secondary Accession #    B2R9Z1; D3DT89 [Other Products]
 UniProt Related Accession #    P28845 [Other Products]
 Molecular Weight    32,401 Da
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 NCBI Official Full Name    corticosteroid 11-beta-dehydrogenase isozyme 1
 NCBI Official Synonym Full Names    hydroxysteroid (11-beta) dehydrogenase 1
 NCBI Official Symbol    HSD11B1 [Similar Products]
 NCBI Official Synonym Symbols   
HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1
[Similar Products]
 NCBI Protein Information    corticosteroid 11-beta-dehydrogenase isozyme 1
 UniProt Protein Name    Corticosteroid 11-beta-dehydrogenase isozyme 1
 UniProt Synonym Protein Names   
11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1; Short chain dehydrogenase/reductase family 26C member 1
 Protein Family    Corticosteroid 11-beta-dehydrogenase isozyme
 UniProt Gene Name    HSD11B1 [Similar Products]
 UniProt Synonym Gene Names    HSD11; HSD11L; SDR26C1; 11-DH; 11-beta-HSD1 [Similar Products]
 UniProt Entry Name    DHI1_HUMAN
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 NCBI Summary for HSD11B1    The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
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 UniProt Comments for HSD11B1    HSD11B1: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol. Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Lipid Metabolism - C21-steroid hormone; Oxidoreductase; Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; EC 1.1.1.146

Chromosomal Location of Human Ortholog: 1q32-q41

Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function: 11-beta-hydroxysteroid dehydrogenase activity

Biological Process: glucocorticoid biosynthetic process; lung development; steroid metabolic process

Disease: Cortisone Reductase Deficiency 2
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 Research Articles on HSD11B1    1. Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11betaHSD1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSD11B1 antibodyPathways associated with anti-HSD11B1 antibody
 Reference Product  PubMed Publications
 CYP11B2 antibody  >4 publications with HSD11B1 and CYP11B2
 CYP11B1 antibody  >4 publications with HSD11B1 and CYP11B1
 HSD3B1 antibody  >4 publications with HSD11B1 and HSD3B1
 HSD3B2 antibody  >3 publications with HSD11B1 and HSD3B2
 PPARG antibody  >2 publications with HSD11B1 and PPARG
 CYP2D6 antibody  >1 publications with HSD11B1 and CYP2D6
 CYP3A4 antibody  >1 publications with HSD11B1 and CYP3A4
 AKR1D1 antibody  >1 publications with HSD11B1 and AKR1D1
 Products by Pathway  Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
 Glucocorticoid Biosynthesis Pathway antibodies  Glucocorticoid Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones Pathway antibodies  Metabolism Of Steroid Hormones Pathway Diagram
Diseases associated with anti-HSD11B1 antibodyOrgans/Tissues associated with anti-HSD11B1 antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >88 publications with HSD11B1 and Obesity
 Insulin Resistance Antibodies  >56 publications with HSD11B1 and Insulin Resistance
 Hypertension Antibodies  >34 publications with HSD11B1 and Hypertension
 Cardiovascular Diseases Antibodies  >22 publications with HSD11B1 and Cardiovascular Diseases
 Obesity, Abdominal Antibodies  >19 publications with HSD11B1 and Obesity, Abdominal
 Liver Diseases Antibodies  >19 publications with HSD11B1 and Liver Diseases
 Inflammation Antibodies  >18 publications with HSD11B1 and Inflammation
 Weight Gain Antibodies  >14 publications with HSD11B1 and Weight Gain
 Necrosis Antibodies  >11 publications with HSD11B1 and Necrosis
 Cortisone reductase deficiency Antibodies  >11 publications with HSD11B1 and Cortisone reductase deficiency
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >84 publications with HSD11B1 and Blood
 Liver Antibodies  >64 publications with HSD11B1 and Liver
 Connective Tissue Antibodies  >52 publications with HSD11B1 and Connective Tissue
 Ovary Antibodies  >27 publications with HSD11B1 and Ovary
 Kidney Antibodies  >24 publications with HSD11B1 and Kidney
 Brain Antibodies  >19 publications with HSD11B1 and Brain
 Muscle Antibodies  >17 publications with HSD11B1 and Muscle
 Lung Antibodies  >13 publications with HSD11B1 and Lung
 Placenta Antibodies  >13 publications with HSD11B1 and Placenta
 Uterus Antibodies  >8 publications with HSD11B1 and Uterus
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