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anti-SERPINA6 antibody :: Rabbit anti-Human, rat Corticosteroid-binding globulin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000651
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Corticosteroid-binding globulin (SERPINA6), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Corticosteroid-binding globulin polyclonal Antibody

 Product Synonym Names    Serpin A6; Transcortin; SERPINA6; CBG;
 Product Gene Name   

anti-SERPINA6 antibody

[Similar Products]
 Product Synonym Gene Name    SERPINA6 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    122500
 3D Structure    ModBase 3D Structure for P08185
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, rat
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Corticosteroid-binding globulin protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SERPINA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SERPINA6 antibody

   Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.
 Product Categories/Family for anti-SERPINA6 antibody    Transport
 Applications Tested/Suitable for anti-SERPINA6 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SERPINA6 antibody    Recommended dilution: WB:1:500-2000
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 Western Blot (WB) of anti-SERPINA6 antibody    Western blot
All lanes: Corticosteroid-binding globulin antibody at 2ug/ml+rat liver tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 45kDa
Observed band size: 45kDa

anti-SERPINA6 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SERPINA6 antibody    Immunohistochemistry of paraffin-embedded human liver tissue using MBS7000651 at dilution of 1:100
anti-SERPINA6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SERPINA6. It may not necessarily be applicable to this product.
 NCBI GI #    73858564
 NCBI GeneID    866
 NCBI Accession #    NP_001747.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001756.3 [Other Products]
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 UniProt Primary Accession #    P08185 [Other Products]
 UniProt Secondary Accession #    Q7Z2Q9; A8K456 [Other Products]
 UniProt Related Accession #    P08185 [Other Products]
 Molecular Weight    45,141 Da [Similar Products]
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 NCBI Official Full Name    corticosteroid-binding globulin
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
 NCBI Official Symbol    SERPINA6 [Similar Products]
 NCBI Official Synonym Symbols   
CBG
[Similar Products]
 NCBI Protein Information    corticosteroid-binding globulin
 UniProt Protein Name    Corticosteroid-binding globulin
 UniProt Synonym Protein Names   
Serpin A6; Transcortin
 Protein Family    Corticosteroid-binding globulin
 UniProt Gene Name    SERPINA6 [Similar Products]
 UniProt Synonym Gene Names    CBG; CBG [Similar Products]
 UniProt Entry Name    CBG_HUMAN
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 NCBI Summary for SERPINA6    This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPINA6    SERPINA6: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency). CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity; steroid binding

Biological Process: glucocorticoid metabolic process; transport

Disease: Corticosteroid-binding Globulin Deficiency
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 Research Articles on SERPINA6    1. SERPINA6-rs1998056 regulated by FOXA/ERalpha might be associated with female HCC risk
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SERPINA6 antibodyDiseases associated with anti-SERPINA6 antibody
 Reference Product  PubMed Publications
 POMC antibody  >12 publications with SERPINA6 and POMC
 CRH antibody  >2 publications with SERPINA6 and CRH
 SHBG antibody  >2 publications with SERPINA6 and SHBG
 ALB antibody  >1 publications with SERPINA6 and ALB
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with SERPINA6 and Nervous System Diseases
 Liver Diseases Antibodies  >3 publications with SERPINA6 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with SERPINA6 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with SERPINA6 and Liver Neoplasms
 Prenatal Exposure Delayed Effects Antibodies  >2 publications with SERPINA6 and Prenatal Exposure Delayed Effects
 Inflammation Antibodies  >2 publications with SERPINA6 and Inflammation
 Cardiovascular Diseases Antibodies  >1 publications with SERPINA6 and Cardiovascular Diseases
 Hypertension Antibodies  >1 publications with SERPINA6 and Hypertension
 Heart Diseases Antibodies  >1 publications with SERPINA6 and Heart Diseases
 Prenatal Injuries Antibodies  >1 publications with SERPINA6 and Prenatal Injuries
Organs/Tissues associated with anti-SERPINA6 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >14 publications with SERPINA6 and Liver
 Ovary Antibodies  >3 publications with SERPINA6 and Ovary
 Heart Antibodies  >2 publications with SERPINA6 and Heart
 Kidney Antibodies  >2 publications with SERPINA6 and Kidney
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