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anti-SLC6A8 antibody :: Goat Creatine transporter 1/SLC6A8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422659
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Creatine transporter 1/SLC6A8, Polyclonal Antibody

 Also Known As   

Goat anti-Creatine transporter 1/SLC6A8 Antibody

 Product Synonym Names    SLC6A8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8; CRT; CRTR; CT1; MGC87396; creatine transporter 1; creatine transporter SLC6A8; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 member 8; SLC6A8 antibody; solute carrier family 6 (neurotransmitter transporter; creatine); member 8 antibody; CRT antibody; CRTR antibody; CT1 antibody; MGC87396 antibody; creatine transporter 1 antibody; creatine transporter SLC6A8 antibody; sodium- and chloride-dependent creatine transporter 1 antibody; Creatine transporter 1; Creatine transporter 1 / SLC6A8
 Product Gene Name   

anti-SLC6A8 antibody

[Similar Products]
 Antibody/Peptide Pairs    Creatine transporter 1 / SLC6A8 peptide (MBS427584) is used for blocking the activity of Creatine transporter 1/SLC6A8 antibody (MBS422659)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ASLANLTCDQ LADRR
 OMIM    300036
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence ASLANLTCDQLADRR, from the internal region of the protein sequence according to NP_005620.1; NP_001136277.1; NP_001136278.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize all reported isoforms (NP_005620.1; NP_001136277.1; NP_001136278.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SLC6A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SLC6A8 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SLC6A8 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 70kDa band observed in Mouse Heart, Kidney and Skeletal Muscle lysates (calculated MW of 71. 0kDa according to Mouse NP_598748.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-SLC6A8 antibody    (0.1ug/ml) staining of Mouse Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SLC6A8 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SLC6A8. It may not necessarily be applicable to this product.
 NCBI GI #    5032097
 NCBI GeneID    6535
 NCBI Accession #    NP_005620.1 [Other Products]
 NCBI Related Accession #    NP_001136277.1; NP_001136278.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005629.3 [Other Products]
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 UniProt Secondary Accession #    Q13032; Q66I36; B2KY47; B4DIA3; E9PFC0 [Other Products]
 UniProt Related Accession #    P48029 [Other Products]
 Molecular Weight    58,453 Da
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 NCBI Official Full Name    sodium- and chloride-dependent creatine transporter 1 isoform 1
 NCBI Official Synonym Full Names    solute carrier family 6 member 8
 NCBI Official Symbol    SLC6A8 [Similar Products]
 NCBI Official Synonym Symbols   
CRT; CT1; CRTR; CTR5; CCDS1
[Similar Products]
 NCBI Protein Information    sodium- and chloride-dependent creatine transporter 1
 UniProt Protein Name    Sodium- and chloride-dependent creatine transporter 1
 UniProt Synonym Protein Names   
Solute carrier family 6 member 8
 Protein Family    Sodium- and chloride-dependent creatine transporter
 UniProt Gene Name    SLC6A8 [Similar Products]
 UniProt Synonym Gene Names    CT1; Creatine transporter 1 [Similar Products]
 UniProt Entry Name    SC6A8_HUMAN
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 NCBI Summary for SLC6A8    The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
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 UniProt Comments for SLC6A8    SLC6A8: Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Motility/polarity/chemotaxis; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: creatine transporter activity; creatine:sodium symporter activity; neurotransmitter:sodium symporter activity

Biological Process: creatine metabolic process; creatine transport; muscle contraction; neurotransmitter transport; sodium ion transport; transport

Disease: Cerebral Creatine Deficiency Syndrome 1
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 Research Articles on SLC6A8    1. both BCAP31 and ABCD1 were associated with hepatic cholestasis and death before 1 year. Remarkably, a patient with an isolated deletion at the 3'-end of SLC6A8 had a similar severe phenotype as seen in BCAP31 deficiency
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SLC6A8 antibodyDiseases associated with anti-SLC6A8 antibody
 Products by Pathway  Pathway Diagram
 Creatine Metabolism Pathway antibodies  Creatine Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Polyamines Pathway antibodies  Metabolism Of Polyamines Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >68 publications with SLC6A8 and Nervous System Diseases
 Mental Retardation, X-Linked Antibodies  >56 publications with SLC6A8 and Mental Retardation, X-Linked
 Brain Diseases Antibodies  >47 publications with SLC6A8 and Brain Diseases
 Seizures Antibodies  >24 publications with SLC6A8 and Seizures
 Creatine deficiency, X-linked Antibodies  >17 publications with SLC6A8 and Creatine deficiency, X-linked
 Autistic Disorder Antibodies  >12 publications with SLC6A8 and Autistic Disorder
 Movement Disorders Antibodies  >11 publications with SLC6A8 and Movement Disorders
 Developmental Disabilities Antibodies  >8 publications with SLC6A8 and Developmental Disabilities
 Congenital Abnormalities Antibodies  >6 publications with SLC6A8 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >5 publications with SLC6A8 and Disease Models, Animal
Organs/Tissues associated with anti-SLC6A8 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >105 publications with SLC6A8 and Brain
 Blood Antibodies  >34 publications with SLC6A8 and Blood
 Muscle Antibodies  >30 publications with SLC6A8 and Muscle
 Kidney Antibodies  >14 publications with SLC6A8 and Kidney
 Heart Antibodies  >13 publications with SLC6A8 and Heart
 Liver Antibodies  >8 publications with SLC6A8 and Liver
 Embryonic Tissue Antibodies  >3 publications with SLC6A8 and Embryonic Tissue
 Testis Antibodies  >3 publications with SLC6A8 and Testis
 Eye Antibodies  >3 publications with SLC6A8 and Eye
 Intestine Antibodies  >3 publications with SLC6A8 and Intestine
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