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anti-CRY2 antibody :: Rabbit anti-Human Cryptochrome-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1497526
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cryptochrome-2 (CRY2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Cryptochrome-2 polyclonal Antibody(CRY2)

 Product Synonym Names    CRY2; KIAA0658
 Product Gene Name   

anti-CRY2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603732
 3D Structure    ModBase 3D Structure for Q49AN0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Cryptochrome-2 protein(434-593aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5954 / sc-33178 / sc-130731
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CRY2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CRY2 antibody

   Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of NAMPT.
 Applications Tested/Suitable for anti-CRY2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CRY2 antibody    Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
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 Western Blot (WB) of anti-CRY2 antibody    All lanes: Cryptochrome-2 antibody at 14ug/ml+Hepg2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 67,61 kDa
Observed band size: 67 kDa

anti-CRY2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CRY2 antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS1497526 at dilution 1:100
anti-CRY2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CRY2. It may not necessarily be applicable to this product.
 NCBI GI #    188536103
 NCBI GeneID    1408
 NCBI Accession #    NP_001120929.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001127457.2 [Other Products]
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 UniProt Primary Accession #    Q49AN0 [Other Products]
 UniProt Secondary Accession #    O75148; Q8IV71; B4DH32; B4DZD6 [Other Products]
 UniProt Related Accession #    Q49AN0 [Other Products]
 Molecular Weight    60,593 Da
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 NCBI Official Full Name    cryptochrome-2 isoform 2
 NCBI Official Synonym Full Names    cryptochrome circadian clock 2
 NCBI Official Symbol    CRY2 [Similar Products]
 NCBI Official Synonym Symbols   
HCRY2; PHLL2
[Similar Products]
 NCBI Protein Information    cryptochrome-2
 UniProt Protein Name    Cryptochrome-2
 Protein Family    Cryptochrome
 UniProt Gene Name    CRY2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0658 [Similar Products]
 UniProt Entry Name    CRY2_HUMAN
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 NCBI Summary for CRY2    This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
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 UniProt Comments for CRY2    CRY2: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL. Belongs to the DNA photolyase class-1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lyase; DNA-binding

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: cytoplasm; extracellular region; nucleus

Molecular Function: blue light photoreceptor activity; damaged DNA binding; deoxyribodipyrimidine photo-lyase activity; DNA (6-4) photolyase activity; DNA binding; phosphatase binding; protein binding; single-stranded DNA binding; ubiquitin binding

Biological Process: blue light signaling pathway; circadian regulation of gene expression; circadian rhythm; entrainment of circadian clock by photoperiod; glucose homeostasis; negative regulation of circadian rhythm; negative regulation of phosphoprotein phosphatase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; photoreactive repair; protein-chromophore linkage; regulation of circadian rhythm; transcription, DNA-dependent
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 Research Articles on CRY2    1. these observations suggest a biologically plausible season-dependent association between SNPs at CRY1, CRY2 and MTNR1B and glucose homeostasis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRY2 antibodyPathways associated with anti-CRY2 antibody
 Reference Product  PubMed Publications
 CRY1 antibody  >423 publications with CRY2 and CRY1
 PER2 antibody  >202 publications with CRY2 and PER2
 PER1 antibody  >181 publications with CRY2 and PER1
 ARNTL antibody  >100 publications with CRY2 and ARNTL
 PER3 antibody  >85 publications with CRY2 and PER3
 TIMELESS antibody  >21 publications with CRY2 and TIMELESS
 FBXL3 antibody  >12 publications with CRY2 and FBXL3
 SKP1 antibody  >4 publications with CRY2 and SKP1
 CUL1 antibody  >2 publications with CRY2 and CUL1
 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
Diseases associated with anti-CRY2 antibodyOrgans/Tissues associated with anti-CRY2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >23 publications with CRY2 and Nervous System Diseases
 Liver Diseases Antibodies  >11 publications with CRY2 and Liver Diseases
 Hypertension Antibodies  >10 publications with CRY2 and Hypertension
 Disease Models, Animal Antibodies  >7 publications with CRY2 and Disease Models, Animal
 Brain Diseases Antibodies  >6 publications with CRY2 and Brain Diseases
 Inflammation Antibodies  >6 publications with CRY2 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >6 publications with CRY2 and Carcinoma, Hepatocellular
 Fatty Liver Antibodies  >5 publications with CRY2 and Fatty Liver
 Liver Neoplasms Antibodies  >5 publications with CRY2 and Liver Neoplasms
 Memory Disorders Antibodies  >4 publications with CRY2 and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >128 publications with CRY2 and Brain
 Eye Antibodies  >109 publications with CRY2 and Eye
 Blood Antibodies  >63 publications with CRY2 and Blood
 Liver Antibodies  >58 publications with CRY2 and Liver
 Muscle Antibodies  >29 publications with CRY2 and Muscle
 Nerve Antibodies  >16 publications with CRY2 and Nerve
 Heart Antibodies  >15 publications with CRY2 and Heart
 Kidney Antibodies  >13 publications with CRY2 and Kidney
 Skin Antibodies  >9 publications with CRY2 and Skin
 Connective Tissue Antibodies  >9 publications with CRY2 and Connective Tissue
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