NP_031799.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
beta-crystallin B2
NCBI Official Synonym Full Names
crystallin, beta B2
NCBI Official Synonym Symbols
NCBI Protein Information
beta-crystallin B2
UniProt Protein Name
Beta-crystallin B2
UniProt Synonym Protein Names
Beta-B2 crystallin; Beta-crystallin Bp
NCBI Summary for CRYbB2
This gene is a member of the beta-crystallin family. Beta crystallins, along with alpha and gamma crystallins, are the major proteins found in the eye lens. These proteins maintain the refractive index of the lens whilst also maintaining its transparency. Since lens central fiber cells lose their nuclei during development, crystallins are made and then retained throughout life, making them extremely stable proteins. Beta and gamma crystallins are considered be a superfamily and have a similar domain architecture, including four Greek Key motifs. Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. The protein encoded by this gene may have Ca2+-binding activity and could be associated with potential functions in the hippocampus and in sperm. Targeted knockout of this gene in mouse induces age-related cataract. A chain-terminating mutation in a similar gene in human was found to cause type 2 cerulean cataracts. [provided by RefSeq, Feb 2015]
UniProt Comments for CRYbB2
CRYBB2: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Defects are the cause of congenital cerulean type 2 cataract, sutural cataract with punctate and cerulean opacities, and Coppock-like cataract.
Chromosomal Location of Human Ortholog: 5 F|5 55.38 cM
Molecular Function: identical protein binding; protein homodimerization activity; structural constituent of eye lens
Biological Process: camera-type eye development; visual perception
Research Articles on CRYbB2
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Products associated with anti-CRYbB2 antibody
Pathways associated with anti-CRYbB2 antibody
Diseases associated with anti-CRYbB2 antibody
Organs/Tissues associated with anti-CRYbB2 antibody
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