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anti-CDKN2A antibody :: Rabbit Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2015352 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $315 +1 FREE 8GB USB
1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cyclin Dependent Kinase Inhibitor 2A (CDKN2A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2A (CDKN2A)

 Product Gene Name   

anti-CDKN2A antibody

[Similar Products]
 Matching Pairs    Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
Antigen: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2018658)
 Matching Pairs    Unconjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
APC-CY7 Conjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2047538)
 Matching Pairs    Unconjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
PE Conjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2047539)
 Matching Pairs    Unconjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
APC-CY7 Conjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2047540)
 Matching Pairs    Unconjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
Cy3 Conjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2047541)
 Matching Pairs    Unconjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
FITC Conjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2047542)
 Matching Pairs    Unconjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
HRP Conjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2047543)
 Matching Pairs    Unconjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2015352)
Biotin Conjugated Antibody: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) (MBS2092497)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2015352 Technical Datasheet    Technical Datasheet PDF
 3D Structure    ModBase 3D Structure for P51480
 Clonality    Polyclonal
 Host    Rabbit
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 Purity/Purification    Antigen-specific affinity chromatography followed by Protein A affinity chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 Concentration    0.72 mg/ml (lot specific)
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 Organism Species    Mus musculus (Mouse)
 Source    Polyclonal antibody preparation
 Immunogen    Recombinant CDKN2A (Ser3~Thr154) expressed in E.coli
 Traits    Liquid
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2047540
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-CDKN2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CDKN2A antibody   

WB; IHC; ICC; IP

 Application Notes for anti-CDKN2A antibody    Western blotting: 0.5-2 ug/mL;1:360-1400
Immunohistochemistry: 5-20 ug/mL;1:36-140
Immunocytochemistry: 5-20 ug/mL;1:36-140

Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-CDKN2A antibody    Figure. Western Blot; Sample:Recombinant CDKN2A, Mouse
anti-CDKN2A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CDKN2A antibody    (Used in DAB staining on formalin fixed paraffin-embedded Spleen tissue)
anti-CDKN2A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CDKN2A. It may not necessarily be applicable to this product.
 NCBI GI #    98986447
 NCBI GeneID    12578
 NCBI Accession #    NP_001035744.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040654.1 [Other Products]
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 UniProt Primary Accession #    P51480 [Other Products]
 UniProt Secondary Accession #    O89088; P97510; P97937; Q6PEA2; Q78E39; Q78E57; Q792X7; Q9QWH6; Q9QWH7; A2ANM1; A2ANM2 [Other Products]
 UniProt Related Accession #    Q64364; P51480 [Other Products]
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 NCBI Official Full Name    cyclin-dependent kinase inhibitor 2A p16INK4a
 NCBI Official Synonym Full Names    cyclin-dependent kinase inhibitor 2A
 NCBI Official Symbol    Cdkn2a [Similar Products]
 NCBI Official Synonym Symbols   
Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19<ARF>; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a)
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase inhibitor 2A
 UniProt Protein Name    Cyclin-dependent kinase inhibitor 2A
 UniProt Synonym Protein Names   
Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16-INK4
 Protein Family    Cyclin-dependent kinase inhibitor
 UniProt Gene Name    Cdkn2a [Similar Products]
 UniProt Synonym Gene Names    CDK4I; p16-INK4 [Similar Products]
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 UniProt Comments for CDKN2A    p16-INK4A: a cell-cycle regulatory protein that interacts with CDK4 and CDK6, inhibiting their ability to interact with cyclins D. Inhibits the phosphorylation of the retinoblastoma protein by CDK4 or CDK6, and entry into the S phase of the cell cycle. The p16INK4A and p14ARF proteins are encoded by CDKN2A, a known tumour suppressor gene in multiple cancers. CDKN2A is inactivated in 72% of cases of lung squamous cell carcinoma: 21% by epigenetic silencing by methylation, 18% inactivating mutation, 4% by exon 1b skipping, and 29% by homozygous deletion. Defects in CDKN2A are the cause of familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, Li-Fraumeni syndrome, and the melanoma-astrocytoma syndrome. The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma. Four alternatively spliced p16 isoforms have been reported. Two alternatively spliced isoforms of ARF have been reported.

Protein type: Cell cycle regulation; Nucleolus; Tumor suppressor

Chromosomal Location of Human Ortholog: 4 C4|4 42.15 cM

Cellular Component: cytoplasm; granular component; mitochondrion; nuclear body; nucleolus; nucleoplasm; nucleus; protein complex; senescence-associated heterochromatin focus

Molecular Function: cyclin-dependent protein serine/threonine kinase inhibitor activity; DNA binding; DNA binding transcription factor activity; NF-kappaB binding; p53 binding; protein binding; protein kinase binding; protein N-terminus binding; RNA binding; SUMO transferase activity; transcription factor binding; ubiquitin ligase inhibitor activity; ubiquitin-protein transferase inhibitor activity

Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; aging; amyloid fibril formation; apoptosis; apoptotic mitochondrial changes; cell aging; cell cycle; cell cycle arrest; cellular response to hydrogen peroxide; cellular senescence; epidermis development; G1/S transition of mitotic cell cycle; glucose homeostasis; mitochondrial depolarization; mitochondrion degradation; negative regulation of B cell proliferation; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of hepatocyte proliferation; negative regulation of immature T cell proliferation in the thymus; negative regulation of mammary gland epithelial cell proliferation; negative regulation of NF-kappaB transcription factor activity; negative regulation of phosphorylation; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein neddylation; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of transcription, DNA-dependent; negative regulation of ubiquitin protein ligase activity; negative regulation of ubiquitin-protein ligase activity; positive regulation of apoptosis; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of cell cycle arrest; positive regulation of cellular senescence; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of gene expression; positive regulation of macrophage apoptotic process; positive regulation of protein localization to nucleus; positive regulation of protein sumoylation; positive regulation of smooth muscle cell apoptotic process; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein destabilization; protein polyubiquitination; protein stabilization; regulation of cyclin-dependent protein kinase activity; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; regulation of nucleocytoplasmic transport; regulation of protein export from nucleus; regulation of protein stability; regulation of transcription, DNA-templated; replicative senescence; response to drug; response to organic cyclic compound; response to organonitrogen compound; rRNA processing; rRNA transcription; senescence-associated heterochromatin focus assembly; somatic stem cell division; somatic stem cell maintenance; transcription, DNA-dependent
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 Research Articles on CDKN2A    1. p16(INK4a) modulates epicardial adipose tissue development, providing a potential mechanistic link between the genetic association of the CDKN2A/B locus and cardiovascular disease risk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDKN2A antibodyPathways associated with anti-CDKN2A antibody
 Reference Product  PubMed Publications
 Trp53 antibody  >1975 publications with CDKN2A and Trp53
 Cdk4 antibody  >1065 publications with CDKN2A and Cdk4
 Myc antibody  >482 publications with CDKN2A and Myc
 Mdm2 antibody  >387 publications with CDKN2A and Mdm2
 Rassf1 antibody  >215 publications with CDKN2A and Rassf1
 Bmi1 antibody  >167 publications with CDKN2A and Bmi1
 Bcl2 antibody  >92 publications with CDKN2A and Bcl2
 Pdgfrb antibody  >24 publications with CDKN2A and Pdgfrb
 Mdm4 antibody  >14 publications with CDKN2A and Mdm4
 Hras1 antibody  >1 publications with CDKN2A and Hras1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Signaling Pathway antibodies  Cell Cycle Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 G1 To S Cell Cycle Control Pathway antibodies  G1 To S Cell Cycle Control Pathway Diagram
Diseases associated with anti-CDKN2A antibodyOrgans/Tissues associated with anti-CDKN2A antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1367 publications with CDKN2A and Adenocarcinoma
 Urogenital Neoplasms Antibodies  >1294 publications with CDKN2A and Urogenital Neoplasms
 Melanoma Antibodies  >1065 publications with CDKN2A and Melanoma
 Lymphoma Antibodies  >740 publications with CDKN2A and Lymphoma
 Lung Neoplasms Antibodies  >699 publications with CDKN2A and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >524 publications with CDKN2A and Neoplasms, Experimental
 Glioma Antibodies  >524 publications with CDKN2A and Glioma
 Pancreatic Neoplasms Antibodies  >490 publications with CDKN2A and Pancreatic Neoplasms
 Breast Neoplasms Antibodies  >464 publications with CDKN2A and Breast Neoplasms
 Brain Neoplasms Antibodies  >452 publications with CDKN2A and Brain Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >857 publications with CDKN2A and Lung
 Mixed Antibodies  >105 publications with CDKN2A and Mixed
 Embryonic Tissue Antibodies  >102 publications with CDKN2A and Embryonic Tissue
 Connective Tissue Antibodies  >65 publications with CDKN2A and Connective Tissue
 Joint Antibodies  >65 publications with CDKN2A and Joint
 Mammary Gland Antibodies  >53 publications with CDKN2A and Mammary Gland
 Spleen Antibodies  >38 publications with CDKN2A and Spleen
 Uncharacterized Tissue Antibodies  >1 publications with CDKN2A and Uncharacterized Tissue
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