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anti-CCNE1 antibody :: Rabbit Cyclin E1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS194213 anti-CCNE1 antibody
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cyclin E1 (CCNE1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Cyclin E1 Polyclonal Antibody

 Product Synonym Names    Anti-Cyclin E1; Cyclin E1
 Product Gene Name   

anti-CCNE1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (30302901..30315219). Location: 19q12
 OMIM    123837
 3D Structure    ModBase 3D Structure for P24864
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 Clonality    Polyclonal
 Host    Rabbit
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 Specificity    Anti-Cyclin E1 [Rabbit antibody to peptide corresponding to aa 43-52 of human cyclin E1]
This antibody recognizes human cyclin E1, a protein (approx. 50 kD) expressed in elevated levels in human tumor cells. Cyclin E1 controls the initiation of DNA synthesis by activating cdk2, and i expression of cyclin E1 is upregulated by the E7 oncoprotein.
 Form/Format    100 ug affinity-purified antibodyin PBS, pH 7.4
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 Antigen    Peptide corresponding toamino acids 43-52 of cyclin E1.
 Stabilizer    None
 Preservatives    0.02% sodium azide.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.
 Other Notes    Small volumes of anti-CCNE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CCNE1 antibody    Cancer Research Products
 Applications Tested/Suitable for anti-CCNE1 antibody   

Immunoblot

 Application Notes for anti-CCNE1 antibody    Immunoblotting: use at 1:500-1:1,000.
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NCBI/Uniprot data below describe general gene information for CCNE1. It may not necessarily be applicable to this product.
 NCBI GI #    23273784
 NCBI GeneID    898
 NCBI Accession #    AAH35498.1 [Other Products]
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 UniProt Primary Accession #    P24864 [Other Products]
 UniProt Secondary Accession #    Q14091; Q8NFG1; Q92501; Q9UD21; A8K684 [Other Products]
 UniProt Related Accession #    P24864 [Other Products]
 Molecular Weight    47,077 Da [Similar Products]
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 NCBI Official Full Name    Cyclin E1
 NCBI Official Synonym Full Names    cyclin E1
 NCBI Official Symbol    CCNE1 [Similar Products]
 NCBI Official Synonym Symbols   
CCNE
[Similar Products]
 NCBI Protein Information    G1/S-specific cyclin-E1; cyclin Es; cyclin Et
 UniProt Protein Name    G1/S-specific cyclin-E1
 UniProt Gene Name    CCNE1 [Similar Products]
 UniProt Synonym Gene Names    CCNE [Similar Products]
 UniProt Entry Name    CCNE1_HUMAN
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 NCBI Summary for CCNE1    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq]
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 UniProt Comments for CCNE1    CCNE1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described.

Protein type: Activator; Nuclear receptor co-regulator; Cell cycle regulation

Chromosomal Location of Human Ortholog: 19q12

Cellular Component: nucleoplasm; cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleus

Molecular Function: protein binding; androgen receptor binding; transcription coactivator activity; kinase activity; cyclin-dependent protein kinase regulator activity; protein kinase binding

Biological Process: G1/S-specific transcription in mitotic cell cycle; Wnt receptor signaling pathway; DNA replication initiation; cell division; regulation of cell cycle; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; mitotic cell cycle; regulation of protein kinase activity; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle
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 Research Articles on CCNE1    1. This study is the first to demonstrate that K(+) channels such as hEag1 are directly involved in the IGF-1-induced up-regulation of cyclin D1 and E expression in MCF-7 cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCNE1 antibodyPathways associated with anti-CCNE1 antibody
 Reference Product  PubMed Publications
 CDK2 antibody  >38 publications with CCNE1 and CDK2
 CDKN1B antibody  >21 publications with CCNE1 and CDKN1B
 CDKN1A antibody  >20 publications with CCNE1 and CDKN1A
 CDK1 antibody  >5 publications with CCNE1 and CDK1
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cyclin A:Cdk2-associated Events At S Phase Entry Pathway antibodies  Cyclin A:Cdk2-associated Events At S Phase Entry Pathway Diagram
 Cyclin E Associated Events During G1/S Transition Pathway antibodies  Cyclin E Associated Events During G1/S Transition Pathway Diagram
Diseases associated with anti-CCNE1 antibodyOrgans/Tissues associated with anti-CCNE1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >102 publications with CCNE1 and Neoplasms
 Carcinoma Antibodies  >39 publications with CCNE1 and Carcinoma
 Skin Diseases Antibodies  >35 publications with CCNE1 and Skin Diseases
 Breast Neoplasms Antibodies  >34 publications with CCNE1 and Breast Neoplasms
 Urogenital Neoplasms Antibodies  >27 publications with CCNE1 and Urogenital Neoplasms
 Female Urogenital Diseases Antibodies  >26 publications with CCNE1 and Female Urogenital Diseases
 Adenocarcinoma Antibodies  >21 publications with CCNE1 and Adenocarcinoma
 Endocrine Gland Neoplasms Antibodies  >20 publications with CCNE1 and Endocrine Gland Neoplasms
 Genital Neoplasms, Female Antibodies  >19 publications with CCNE1 and Genital Neoplasms, Female
 Ovarian Neoplasms Antibodies  >17 publications with CCNE1 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >9 publications with CCNE1 and Liver
 Lung Antibodies  >7 publications with CCNE1 and Lung
 Skin Antibodies  >5 publications with CCNE1 and Skin
 Kidney Antibodies  >5 publications with CCNE1 and Kidney
 Prostate Antibodies  >3 publications with CCNE1 and Prostate
 Heart Antibodies  >2 publications with CCNE1 and Heart
 Uterus Antibodies  >2 publications with CCNE1 and Uterus
 Embryonic Tissue Antibodies  >2 publications with CCNE1 and Embryonic Tissue
 Intestine Antibodies  >2 publications with CCNE1 and Intestine
 Placenta Antibodies  >2 publications with CCNE1 and Placenta
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