NP_775545.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,288 Da
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase CYLD isoform b
NCBI Official Synonym Full Names
cylindromatosis (turban tumor syndrome)
NCBI Official Synonym Symbols
EAC; CDMT; CYLD1; mKIAA0849; 2010013M14Rik; 2900009M21Rik; C130039D01Rik [Similar Products]
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase CYLD
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase CYLD
UniProt Synonym Protein Names
Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD
UniProt Synonym Gene Names
UniProt Entry Name
CYLD_MOUSE
NCBI Summary for Cyld
This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
UniProt Comments for Cyld
CYLD: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region). Interacts with TRAF2 and TRIP. Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and DDX58. Interacts (via CAP-Gly domain) with microtubules. Interacts with HDAC6 and BCL3. Interacts with SQSTM1 and MAP3K7. Identified in a complex with TRAF6 and SQSTM1. Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. Inhibited by phosphorylation at serine residues. Belongs to the peptidase C67 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Ubiquitin-specific protease; EC 3.4.19.12; Protease; Tumor suppressor
Cellular Component: cell projection; centrosome; cytoplasm; cytoplasmic microtubule; cytoskeleton; cytosol; extrinsic to internal side of plasma membrane; membrane; microtubule; midbody; plasma membrane; spindle
Molecular Function: cysteine-type peptidase activity; hydrolase activity; metal ion binding; peptidase activity; protein binding; protein kinase binding; ubiquitin-specific protease activity; zinc ion binding
Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of NF-kappaB import into nucleus; negative regulation of T cell differentiation; protein deubiquitination; proteolysis; regulation of mitotic cell cycle; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway
Research Articles on Cyld
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Products associated with anti-Cyld antibody
Pathways associated with anti-Cyld antibody
Diseases associated with anti-Cyld antibody
Organs/Tissues associated with anti-Cyld antibody
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