NP_001035814.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
107,044 Da
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase CYLD isoform 2
NCBI Official Synonym Full Names
CYLD lysine 63 deubiquitinase
NCBI Official Synonym Symbols
EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2 [Similar Products]
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase CYLD
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase CYLD
UniProt Synonym Protein Names
Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD
NCBI Summary for CYLD
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for CYLD
CYLD: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region). Interacts with TRAF2 and TRIP. Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and DDX58. Interacts (via CAP-Gly domain) with microtubules. Interacts with HDAC6 and BCL3. Interacts with SQSTM1 and MAP3K7. Identified in a complex with TRAF6 and SQSTM1. Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. Inhibited by phosphorylation at serine residues. Belongs to the peptidase C67 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component: centrosome; cytoplasmic microtubule; cytosol; extrinsic component of cytoplasmic side of plasma membrane; midbody; perinuclear region of cytoplasm; spindle
Molecular Function: protein binding; protein kinase binding; structural constituent of ribosome; thiol-dependent ubiquitin-specific protease activity; zinc ion binding
Biological Process: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; cell cycle; homeostasis of number of cells; innate immune response; negative regulation of NF-kappaB import into nucleus; negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell differentiation; negative regulation of type I interferon production; positive regulation of T cell differentiation; positive regulation of T cell receptor signaling pathway; protein deubiquitination; regulation of B cell differentiation; regulation of mitotic cell cycle; regulation of protein binding; ubiquitin-dependent protein catabolic process; Wnt signaling pathway
Disease: Brooke-spiegler Syndrome; Cylindromatosis, Familial; Trichoepithelioma, Multiple Familial, 1
Research Articles on CYLD
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Products associated with anti-CYLD antibody
Pathways associated with anti-CYLD antibody
Diseases associated with anti-CYLD antibody
Organs/Tissues associated with anti-CYLD antibody
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