AAO92297.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 39 Observed MW: 36
NCBI Official Full Name
cysteinyl leukotriene receptor 1
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 1
NCBI Official Synonym Symbols
CYSLT1; CYSLTR; CYSLT1R; HMTMF81 [Similar Products]
NCBI Protein Information
cysteinyl leukotriene receptor 1
UniProt Protein Name
Cysteinyl leukotriene receptor 1
UniProt Synonym Protein Names
Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81
UniProt Synonym Gene Names
UniProt Entry Name
CLTR1_HUMAN
NCBI Summary for CysLTR1
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for CysLTR1
CYSLTR1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq13.2-q21.1
Cellular Component: cytosol; integral to plasma membrane; membrane; plasma membrane
Molecular Function: cysteinyl leukotriene receptor activity; leukotriene receptor activity; peptide receptor activity, G-protein coupled; protein binding
Biological Process: calcium ion transport; cell surface receptor linked signal transduction; chemotaxis; circulatory system process; defense response; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neuropeptide signaling pathway; respiratory gaseous exchange
Research Articles on CysLTR1
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Products associated with anti-CysLTR1 antibody
Pathways associated with anti-CysLTR1 antibody
Diseases associated with anti-CysLTR1 antibody
Organs/Tissues associated with anti-CysLTR1 antibody
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