Q5T277
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cysteine conjugate-beta lyase, cytoplasmic
NCBI Official Synonym Full Names
cysteine conjugate-beta lyase, cytoplasmic
NCBI Official Synonym Symbols
GTK; KAT1; KATI; FLJ95217; MGC29624 [Similar Products]
NCBI Protein Information
kynurenine--oxoglutarate transaminase 1; OTTHUMP00000022311; OTTHUMP00000022312; beta-lysase, kidney; glutamine transaminase K; kyneurenine aminotransferase; kynurenine aminotransferase I; cysteine-S-conjugate beta-lyase; glutamine--phenylpyruvate transaminase; kynurenine--oxoglutarate transaminase I; glutamine-phenylpyruvate aminotransferase; cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)
UniProt Protein Name
Kynurenine--oxoglutarate transaminase 1
UniProt Synonym Protein Names
Kynurenine--oxoglutarate transaminase 1
UniProt Entry Name
Q5T277_HUMAN
NCBI Summary for CCBL1
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq]
UniProt Comments for CCBL1
CCBL1: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Lyase; Transferase; EC 2.6.1.64; EC 4.4.1.13; EC 2.6.1.7
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: nucleoplasm; cytoplasm; cytosol
Molecular Function: cysteine-S-conjugate beta-lyase activity; protein homodimerization activity; kynurenine-oxoglutarate transaminase activity; glutamine-pyruvate transaminase activity; glutamine-phenylpyruvate transaminase activity; transaminase activity; phenylalanine(histidine) transaminase activity; pyridoxal phosphate binding
Biological Process: L-phenylalanine catabolic process; amino acid biosynthetic process; tryptophan catabolic process; amino acid derivative metabolic process
Research Articles on CCBL1
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Pathways associated with anti-CCBL1 antibody
Diseases associated with anti-CCBL1 antibody
Organs/Tissues associated with anti-CCBL1 antibody
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