NP_006630.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cysteinyl leukotriene receptor 1
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 1
NCBI Official Synonym Symbols
CYSLT1; CYSLTR; CYSLT1R; HMTMF81 [Similar Products]
NCBI Protein Information
cysteinyl leukotriene receptor 1; LTD4 receptor; G-protein coupled receptor HG55; cysteinyl leukotriene D4 receptor
UniProt Protein Name
Cysteinyl leukotriene receptor 1
UniProt Synonym Protein Names
Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81
UniProt Synonym Gene Names
UniProt Entry Name
CLTR1_HUMAN
NCBI Summary for CYSLTR1
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for CYSLTR1
Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
Miscellaneous: Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Research Articles on CYSLTR1
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Products associated with anti-CYSLTR1 antibody
Pathways associated with anti-CYSLTR1 antibody
Diseases associated with anti-CYSLTR1 antibody
Organs/Tissues associated with anti-CYSLTR1 antibody
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