NP_000761.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 56 kDa
NCBI Official Full Name
cytochrome P450 2C8 isoform a
NCBI Official Synonym Full Names
cytochrome P450 family 2 subfamily C member 8
NCBI Official Synonym Symbols
CPC8; CYPIIC8; CYP2C8DM; MP-12/MP-20 [Similar Products]
NCBI Protein Information
cytochrome P450 2C8
UniProt Protein Name
Cytochrome P450 2C8
UniProt Synonym Protein Names
CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase
NCBI Summary for CYP2C8
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for CYP2C8
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
Research Articles on CYP2C8
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Pathways associated with anti-CYP2C8 antibody
Diseases associated with anti-CYP2C8 antibody
Organs/Tissues associated with anti-CYP2C8 antibody
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