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anti-CYP2D6 antibody :: Rabbit anti-Human Cytochrome P450 2D6 (CYP2D6) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2003936 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.02 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $320 +1 FREE 8GB USB
0.2 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 2D6 (CYP2D6), Polyclonal Antibody

 Also Known As   

Polyclonal Antibody to Cytochrome P450 2D6 (CYP2D6)

 Product Gene Name   

anti-CYP2D6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- LHIPALAGKV AFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ AHMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS SVLKDEAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQ
 Chromosome Location    Chromosome: 22; NC_000022.10 (42522501..42526883, complement). Location: 22q13.1
 OMIM    124030
 3D Structure    ModBase 3D Structure for P10635
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against CYP2D6. It has been selected for its ability to recognize CYP2D6 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant CYP2D6 (Leu236~Gln472) expressed in E.coli.
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-CYP2D6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CYP2D6 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CYP2D6 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-CYP2D6 antibody    (Western Blot; Sample: Mouse Liver lysate; Primary Ab: 1ug/ml Rabbit Anti-Human CYP2D6 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
anti-CYP2D6 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-CYP2D6 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-CYP2D6 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CYP2D6 antibody    (Figure.DAB staining on IHC-P. Samples: Human Tissue)
anti-CYP2D6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CYP2D6. It may not necessarily be applicable to this product.
 NCBI GI #    392513723
 NCBI GeneID    1565
 NCBI Accession #    NP_001020332.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025161.2 [Other Products]
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 UniProt Primary Accession #    P10635 [Other Products]
 UniProt Secondary Accession #    Q16752; Q2XND6; Q2XND7; Q2XNE0; Q6B012; Q6NXU8 [Other Products]
 UniProt Related Accession #    P10635 [Other Products]
 Molecular Weight    55,769 Da
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 NCBI Official Full Name    cytochrome P450 2D6 isoform 2
 NCBI Official Synonym Full Names    cytochrome P450, family 2, subfamily D, polypeptide 6
 NCBI Official Symbol    CYP2D6 [Similar Products]
 NCBI Official Synonym Symbols   
CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1
[Similar Products]
 NCBI Protein Information    cytochrome P450 2D6; cytochrome P450-DB1; microsomal monooxygenase; xenobiotic monooxygenase; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2
 UniProt Protein Name    Cytochrome P450 2D6
 UniProt Synonym Protein Names   
CYPIID6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase
 Protein Family    Cytochrome
 UniProt Gene Name    CYP2D6 [Similar Products]
 UniProt Synonym Gene Names    CYP2DL1 [Similar Products]
 UniProt Entry Name    CP2D6_HUMAN
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 NCBI Summary for CYP2D6    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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 UniProt Comments for CYP2D6    CYP2D6: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.14.1; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum

Molecular Function: iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxidoreductase activity; drug binding; oxygen binding; monooxygenase activity

Biological Process: steroid metabolic process; coumarin metabolic process; monoterpenoid metabolic process; isoquinoline alkaloid metabolic process; negative regulation of binding; drug catabolic process; xenobiotic metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process; alkaloid catabolic process; alkaloid metabolic process; heterocycle metabolic process; drug metabolic process

Disease: Drug Metabolism, Poor, Cyp2d6-related
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 Research Articles on CYP2D6    1. CYP2D6 and CYP2C19 genotyping appears advisable before the prescription of tamoxifen therapy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP2D6 antibodyPathways associated with anti-CYP2D6 antibody
 Reference Product  PubMed Publications
 UGT1A1 antibody  >51 publications with CYP2D6 and UGT1A1
 UGT2B7 antibody  >40 publications with CYP2D6 and UGT2B7
 FMO3 antibody  >29 publications with CYP2D6 and FMO3
 UGT1A6 antibody  >11 publications with CYP2D6 and UGT1A6
 UGT1A4 antibody  >10 publications with CYP2D6 and UGT1A4
 UGT1A9 antibody  >9 publications with CYP2D6 and UGT1A9
 UGT1A3 antibody  >6 publications with CYP2D6 and UGT1A3
 UGT1A8 antibody  >5 publications with CYP2D6 and UGT1A8
 UGT1A10 antibody  >2 publications with CYP2D6 and UGT1A10
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 CYP2E1 Reactions Pathway antibodies  CYP2E1 Reactions Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Fatty Acid Omega Oxidation Pathway antibodies  Fatty Acid Omega Oxidation Pathway Diagram
 Fatty Acids Pathway antibodies  Fatty Acids Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
Diseases associated with anti-CYP2D6 antibodyOrgans/Tissues associated with anti-CYP2D6 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >613 publications with CYP2D6 and Mental Disorders
 Breast Neoplasms Antibodies  >265 publications with CYP2D6 and Breast Neoplasms
 Depressive Disorder Antibodies  >185 publications with CYP2D6 and Depressive Disorder
 Movement Disorders Antibodies  >144 publications with CYP2D6 and Movement Disorders
 Basal Ganglia Diseases Antibodies  >139 publications with CYP2D6 and Basal Ganglia Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >110 publications with CYP2D6 and Drug-Related Side Effects and Adverse Reactions
 Parkinson Disease Antibodies  >96 publications with CYP2D6 and Parkinson Disease
 Substance-Related Disorders Antibodies  >90 publications with CYP2D6 and Substance-Related Disorders
 Nausea Antibodies  >63 publications with CYP2D6 and Nausea
 Hypertension Antibodies  >56 publications with CYP2D6 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1574 publications with CYP2D6 and Liver
 Blood Antibodies  >1149 publications with CYP2D6 and Blood
 Brain Antibodies  >212 publications with CYP2D6 and Brain
 Intestine Antibodies  >66 publications with CYP2D6 and Intestine
 Mouth Antibodies  >31 publications with CYP2D6 and Mouth
 Prostate Antibodies  >19 publications with CYP2D6 and Prostate
 Spleen Antibodies  >10 publications with CYP2D6 and Spleen
 Uterus Antibodies  >10 publications with CYP2D6 and Uterus
 Testis Antibodies  >5 publications with CYP2D6 and Testis
 Mammary Gland Antibodies  >3 publications with CYP2D6 and Mammary Gland
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