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anti-CYP2F1 antibody :: Rabbit anti-Human Cytochrome P450 2F1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1496173
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 2F1 (CYP2F1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Cytochrome P450 2F1 polyclonal Antibody(CYP2F1)

 Product Synonym Names    CYPIIF1; CYP2F1
 Product Gene Name   

anti-CYP2F1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    124070
 3D Structure    ModBase 3D Structure for P24903
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Cytochrome P450 2F1 protein (100-290aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66360 / sc-67283 / sc-67282
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CYP2F1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CYP2F1 antibody

   May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.
 Applications Tested/Suitable for anti-CYP2F1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CYP2F1 antibody    Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
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 Western Blot (WB) of anti-CYP2F1 antibody    All lanes: Cytochrome P450 2F1 antibody at 8ug/ml+A549 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 56,37 kDa
Observed band size: 56 kDa

anti-CYP2F1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CYP2F1 antibody    Immunohistochemistry of paraffin-embedded human lung using MBS1496173 at dilution 1:100
anti-CYP2F1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CYP2F1. It may not necessarily be applicable to this product.
 NCBI GI #    19743565
 NCBI GeneID    1572
 NCBI Accession #    NP_000765.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000774.3 [Other Products]
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 UniProt Primary Accession #    P24903 [Other Products]
 UniProt Secondary Accession #    Q32MN5; Q8WWJ2; A7KAU6; A7KAU7; A7KAU8; A7KAU9; A7KAV0 [Other Products]
 UniProt Related Accession #    P24903 [Other Products]
 Molecular Weight    36,410 Da
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 NCBI Official Full Name    cytochrome P450 2F1
 NCBI Official Synonym Full Names    cytochrome P450 family 2 subfamily F member 1
 NCBI Official Symbol    CYP2F1 [Similar Products]
 NCBI Official Synonym Symbols   
C2F1; CYP2F
[Similar Products]
 NCBI Protein Information    cytochrome P450 2F1
 UniProt Protein Name    Cytochrome P450 2F1
 UniProt Synonym Protein Names   
CYPIIF1
 Protein Family    Cytochrome
 UniProt Gene Name    CYP2F1 [Similar Products]
 UniProt Entry Name    CP2F1_HUMAN
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 NCBI Summary for CYP2F1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP2F1    CYP2F2: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Belongs to the cytochrome P450 family.

Protein type: Oxidoreductase; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: arachidonic acid epoxygenase activity; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; steroid hydroxylase activity

Biological Process: epoxygenase P450 pathway; naphthalene metabolic process; response to toxin; trichloroethylene metabolic process; xenobiotic metabolic process
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 Research Articles on CYP2F1    1. Tissue distribution of transgenic mRNA expression agrees well with the known respiratory tract-selective expression of CYP2A13 and CYP2F1 and hepatic expression of CYP2B6 in humans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP2F1 antibodyPathways associated with anti-CYP2F1 antibody
 Reference Product  PubMed Publications
 EPHX1 antibody  >6 publications with CYP2F1 and EPHX1
 GSTP1 antibody  >4 publications with CYP2F1 and GSTP1
 GSTT1 antibody  >2 publications with CYP2F1 and GSTT1
 GSTM1 antibody  >2 publications with CYP2F1 and GSTM1
 MGST2 antibody  >1 publications with CYP2F1 and MGST2
 MGST1 antibody  >1 publications with CYP2F1 and MGST1
 GSTO2 antibody  >1 publications with CYP2F1 and GSTO2
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 CYP2E1 Reactions Pathway antibodies  CYP2E1 Reactions Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Fatty Acids Pathway antibodies  Fatty Acids Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Xenobiotics Pathway antibodies  Xenobiotics Pathway Diagram
Diseases associated with anti-CYP2F1 antibodyOrgans/Tissues associated with anti-CYP2F1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >7 publications with CYP2F1 and Liver Diseases
 Adenocarcinoma Antibodies  >6 publications with CYP2F1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >4 publications with CYP2F1 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >3 publications with CYP2F1 and Neoplasms, Experimental
 Drug-Induced Liver Injury Antibodies  >3 publications with CYP2F1 and Drug-Induced Liver Injury
 Breast Neoplasms Antibodies  >2 publications with CYP2F1 and Breast Neoplasms
 Necrosis Antibodies  >2 publications with CYP2F1 and Necrosis
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with CYP2F1 and Prenatal Exposure Delayed Effects
 Hyperplasia Antibodies  >1 publications with CYP2F1 and Hyperplasia
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with CYP2F1 and Drug-Related Side Effects and Adverse Reactions
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >35 publications with CYP2F1 and Lung
 Trachea Antibodies  >2 publications with CYP2F1 and Trachea
 Pharynx Antibodies  >1 publications with CYP2F1 and Pharynx
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