NP_000766.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cytochrome P450 2J2
NCBI Official Synonym Full Names
cytochrome P450, family 2, subfamily J, polypeptide 2
NCBI Official Synonym Symbols
NCBI Protein Information
cytochrome P450 2J2; CYPIIJ2; microsomal monooxygenase; arachidonic acid epoxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2
UniProt Protein Name
Cytochrome P450 2J2
UniProt Synonym Protein Names
Arachidonic acid epoxygenase; CYPIIJ2
UniProt Entry Name
CP2J2_HUMAN
NCBI Summary for CYP2J2
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP2J2
CYP2J2: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools. Belongs to the cytochrome P450 family.
Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; EC 1.14.14.1; Contractile
Chromosomal Location of Human Ortholog: 1p31.3-p31.2
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm
Molecular Function: arachidonic acid 14,15-epoxygenase activity; iron ion binding; heme binding; arachidonic acid 11,12-epoxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding
Biological Process: xenobiotic metabolic process; exogenous drug catabolic process; icosanoid metabolic process; arachidonic acid metabolic process; linoleic acid metabolic process; epoxygenase P450 pathway; regulation of heart contraction
Research Articles on CYP2J2
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Products associated with anti-CYP2J2 antibody
Pathways associated with anti-CYP2J2 antibody
Diseases associated with anti-CYP2J2 antibody
Organs/Tissues associated with anti-CYP2J2 antibody
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